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Human breast adipose tissue extracellular vesicles

ABSTRACT: Proteomic analysis was performed on extracellular vesicles from human breast adipose tissue

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Breast

SUBMITTER: Kristy Brown

LAB HEAD: Kristy Angela Brown

PROVIDER: PXD045471 | Pride | 2023-12-04

REPOSITORIES: Pride

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Breast adipose tissue-derived extracellular vesicles from obese women alter tumor cell metabolism.

Liu Shuchen S Benito-Martin Alberto A Pelissier Vatter Fanny A FA Hanif Sarah Z SZ Liu Catherine C Bhardwaj Priya P Sethupathy Praveen P Farghli Alaa R AR Piloco Phoebe P Paik Paul P Mushannen Malik M Dong Xue X Otterburn David M DM Cohen Leslie L Bareja Rohan R Krumsiek Jan J Cohen-Gould Leona L Calto Samuel S Spector Jason A JA Elemento Olivier O Lyden David C DC Brown Kristy A KA

EMBO reports 20231106 12

Breast adipose tissue is an important contributor to the obesity-breast cancer link. Extracellular vesicles (EVs) are nanosized particles containing selective cargo, such as miRNAs, that act locally or circulate to distant sites to modulate target cell functions. Here, we find that long-term education of breast cancer cells with EVs obtained from breast adipose tissue of women who are overweight or obese (O-EVs) results in increased proliferation. RNA-seq analysis of O-EV-educated cells demonstr ...[more]

PMID: 37929643

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