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Expression data from small intestine of NFKBIA-KO mice versus wild type

ABSTRACT: Expression data from small intestine of NFKBIA-KO mice versus wild type

PROVIDER: PRJNA578908 | ENA |

REPOSITORIES: ENA

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Expression data from small intestine of NFKBIA-KO mice versus wild type

Project description:The IkB-Kinase (IKK)-NF-kB signaling pathway plays a multifaceted role in Inflammatory Bowel Disease: One the one hand it protects cells from apoptosis, but on the other, it activates transcription of numerous inflammatory cytokines and chemokines. To examine the role of constitutive NF-kB signaling in intestinal epithelium cells (IEC), we generated a mouse model with a tissue-specific knockout of the direct inhibitor of NF-kB, IkBα. We demonstrate that in IκBαIEC-KO mice, constitutive activation of NF-kB in epithelium leads to abnormal intestinal development, enlarged peyer’s patches, loss of Paneth cells, and spontaneous inflammation. We performed expression analysis of IκBαIEC-KO mice compared to wildtype by using the Affymetrix array Clariom S mouse.

2020-03-22 | GSE139251 | GEO

Global gene expression profile of small intestine from wild-type and CFTR-knockout mice.

Project description:The objective of this study was to identify changes in gene expression levels between wild-type and CFTR-knockout small intestine. CFTR-knockout mice (provided by Dr. Lane Clarke of the University of Missouri) were maintained on colyte. Keywords: gene expression comparison Four wild-type and four CFTR-knockout small intestinal RNA samples were compared. To facilitate statistical analysis and reduce affects of Cy3 and Cy5 labeling, comparison of two WT and two KO were repeated with a dye flip.

2010-05-25 | E-GEOD-8763 | biostudies-arrayexpress

MOG KO Tregs versus WT Tregs

Project description:Transcriptional comparison of WT Tregs versus MOG KO Tregs

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Expression data for Fat storage inducing transmembrane protein 2 (FIT2/FITM2)-deleted small intestine

Project description:Tamoxifen- induced FIT2 deletion using whole body inducible ROSA26CreERT2 FIT2 floxed mice causes upregulation of the p53 pathway which accompanies intestinal death We used microarrays to detail the changes in small intestine gene expression at day 2, 3, and 5 of tamoxifen induced FIT2 deletion in whole body inducible ROSA26CreERT2 FIT2 floxed mice. Small intestine was harvested from L/L and ROSA26CreERT2 L/L mice at days 2, 3, and 5 post- tamoxifen treatment and subject to microarray analysis. Pooled intestinal RNA from n biological replicates were used for each genotype and timepoint. D2 L/L n=6, D2 KO n=7, D3 L/L n=6, D3 KO n=6, D5 L/L n=8, D5 KO n=7.

2015-07-03 | E-GEOD-70465 | biostudies-arrayexpress

Expression data from wild-type (WT) and lrrc19 gene knockout (KO) mice intestines

Project description:LRRC19 (Leucine repeat receptor containing 19) is a newfound Toll-like receptor without definite function reported. We have detected that the lrrc19 gene had a high expression level in both human and mouse intestines and concentrated on the effect of this immune receptor in mediating the process of enteritis and intestinal cancer. To have a systematic understanding on the influence of this gene on the intracelluar environment of intestinal cell, we have conducted a microarray experiment to compare the transcriptomes of the WT and KO mice intestines under the same experimental condition. Gut epithelial cells of WT and KO mice of the same physiological and maintaining condition were isolated and then total RNAs were extracted from them, which could reflect the respective transcription profile of WT and KO mice. These RNAs were detected by microarray and the influence of lrrc19 gene on intestine could be revealed to some extent.

2014-10-21 | E-GEOD-62487 | biostudies-arrayexpress

Transcription profiling of intestine, kidney and liver tissues from adult male knock-out mice for all Cyp3a genes versus wild type mice

Project description:Comparision of gene expression profiles of intestine, kidney and liver tissues of adult male knock-out mice for all Cyp3a genes (Cyp3a-/- genotype) versus adult male wild-type control mice (FVB genotype).

2007-11-06 | E-NCMF-1 | biostudies-arrayexpress

E47 KO versus WT HSCs

Project description:Genome-wide gene expression pattern of E47 KO versus WT HSCs from primary and secondary recipient mice were analysis using Agilent one-color micro-array analysis.

2011-01-22 | GSE26788 | GEO

Analysis of Wild Type and Whsc1-/- small intestine Transcriptomes

Project description:Analysis of Wild Type and Whsc1-/- small intestine Transcriptomes

| PRJNA743911 | ENA

CASP8 C362A KI MLKL KO e16.5 intestine RNAseq

Project description:CASP8 C362A KI MLKL KO e16.5 intestine RNAseq

| PRJNA516934 | ENA

Single cell RNAseq of Th17 and Th22 cells with Gpr65_WT versus KO

Project description:scRNAseq of in vitro polarized Th17 and Th22 cells (Gpr65_WT versus KO), to compare metabolism gene expression in Gpr65_WT versus KO.

2022-04-12 | GSE182767 | GEO

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