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Nascent RNA sequencing (PRO-seq) after 200nM romidepsin treatment of H9 cells

ABSTRACT: Nascent RNA sequencing (PRO-seq) after 200nM romidepsin treatment of H9 cells

PROVIDER: PRJNA594951 | ENA |

REPOSITORIES: ENA

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Nascent RNA sequencing (PRO-seq) after 200nM romidepsin treatment of H9 cells

Project description:Nascent RNA sequencing (PRO-seq) after 200nM romidepsin treatment of H9 cells

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Nascent RNA sequencing (PRO-seq) after estrogen treatment in T47D cells

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Quantitative RNAseq Analysis of Treatment Outcomes with Talazoparib, Romidepsin or Combination in MBL2 cell line

Project description:To explore the molecular mechanisms by which romidepsin potentiates the effect of talazoparib, RNA sequencing analysis of MBL2 cell lines treated with talazoparib, romidepsin, or talazoparib plus romidepsin was performed. 40% of the 2023 genes in combination were from talazoparib, whereas only 5.9% of the genes deregulated during the treatment with the combination of talazoparib plus romidepsin were from the effect of romidepsin. 94 genes were presented in all three treatment groups and included upregulation of Prdm1, Dusp5, and CD74, among others. Analysis of genes responsible for DNA repair, cell cycle arrest and apoptosis demonstrated the contribution of romidepsin to downregulation of DNA repair, the synergistic effect of romidepsin and talazoparib on downregulation of genes of cell cycle leading to cell cycle arrest, and activation of apoptosis by talazoparib predominantly.

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Effect of Romidepsin treatment on patient-derived liver cancer cells

Project description:Romidepsin displayed potent antitumor activity in our lenvatinib-resistant PDCs, we wanted to investigate the underlying mechanism of how romidepsin initiated susceptibility to conquer lenvatinib resistance in liver cancer.

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4sUDRB-seq of human PA1 cells, undifferentiated H9 cells and H9 differentiated FB neurons

Project description:We have optimized the metabolic tagging of newly transcribed RNAs by 4-thiouridine (4sU) to identify newly-transcribed (nascent) circRNAs from human PA1 cells, undifferentiated H9 cells and H9 differentiated FB neurons.

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Expression data of Panc1 cells treated with romidepsin and tamoxifen

Project description:Tamoxifen enhances romidepsin-induced senescence in pancreatic cancer cells. We compared gene-expression profile among untreated control, romidepsin-treated, tamoxifen-treated, and romidepsin plus tamoxifen-treated Panc1 cells.

2021-08-21 | GSE182526 | GEO

Transcriptomic analysis of human cancer cell lines treated with the histone deacetylase inhibitor romidepsin

Project description:Global gene expression analysis was performed on 8 cancer cell lines after treatment with romidepsin for 6h, or 6h treatment followed by 12 h incubation with drug free medium. The cell lines were selected based on their response spectrum to romidepsin, and included HUT78, LOXIMVI, M14, A549, MDA231, ACHN, MiaPaca2 and PC3. Differentially expressed genes (DEG) included genes involved in DNA damage repair (DDR) pathways. The Affymetrix Human Genome U133 Plus 2.0 platform was used for the gene expression profiling.

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Gene expression profiling of cutaneous T cell lymphoma cell lines and primary tumor samples treated with mechlorethamine and romidepsin.

Project description:In this study, we demonstrated the synergistic effect of the mechlorethamine-romidepsin combination in cutaneous T cell lymphoma cell lines and CD4+ T cells derived from patients with Sezary Syndrome. We identify the signaling pathways specifically perturbed under treatment with mechlorethamine-romidepsin combination.

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Expression data of MOLT-4 cells treated with romidepsin and tamoxifen

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ChIP-seq. analysis of pan-histone 3 acetylation in Romidepsin treated TCam-2

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2016-09-01 | E-GEOD-78262 | biostudies-arrayexpress

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