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Single-cell Gene expression of WT and LRF-deficient thymic IEL precusors (IELp)

ABSTRACT: Single-cell Gene expression of WT and LRF-deficient thymic IEL precusors (IELp)

PROVIDER: PRJNA630733 | ENA |

REPOSITORIES: ENA

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Gene expression in WT and LRF-deficient thymic IEL precusors (IELp) and their progeny CD8aa IEL

Project description:Gene expression in WT and LRF-deficient thymic IEL precusors (IELp) and their progeny CD8aa IEL

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Single-cell Gene expression of WT CD8aa IEL and LRF-deficient CD8aa splenocytes

Project description:To examine how the cluster composition of CD8aa IEL and their transcriptomic signatures were affected by LRF disruption, single-cell gene expression of CD8aa IEL from control (Cd4 Cre–Lrffl/fl) and CD8aa splenocytes from LRF KO (Cd4 Cre+Lrffl/fl ) mice were determined by scRNAseq.

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Single-cell Gene expression of WT and LRF-deficient thymic IEL precusors (IELp)

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Expression data from control and LRF-deficient mouse germinal center B cells

Project description:B cells are indispensable for humoral immunity, as they ultimately give rise to antibody-secreting plasma cells. During T cell-dependent antibody responses, naive B cells form germinal centers (GCs), a distinct histologic structure found in secondary lymphoid organs. Naive B cells become activated upon interaction with T cells and antigen presenting cells, and begin to rapidly proliferate and form the characteristic GC structure. To elucidate the overall effect of LRF loss in the GCB cell transcriptome, gene expression microarray analysis of FACS-sorted GCB cells was performed. LRF Flox/+ mb-1 Cre+ mice were used as a control to normalize the potential effects of Cre recombinase, and four RNA samples for each genotype were used for the analysis. B cell-specific LRF knockout (LRF Flox/Flox mb-1 Cre+) and control (LRF Flox/+ mb-1 Cre+) mice (4 each) were immunized with sheep red blood cells, and GCB cells were FACS-sorted 7 days later.

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Expression data from control and LRF (leukemia/lymphoma related factor)-deficient mouse LT-HSCs

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Expression data from control and LRF (leukemia/lymphoma related factor)-deficient mouse LT-HSCs

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