Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Enterobacter mori isolate:enterobacter cloacae complex

ABSTRACT: Enterobacter mori isolate:enterobacter cloacae complex Genome sequencing

PROVIDER: PRJNA663254 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Enterobacter mori isolate:enterobacter cloacae

Project description:Enterobacter mori isolate:enterobacter cloacae Genome sequencing

| PRJNA663366 | ENA

Proteomics analysis of the Enterobacter cloacae response to imipenem

Project description:Recently, we have reported on a highly drug-resistant carbapenemase-producing isolate of Enterobacter cloacae (Nepal et al., Virulence. 2018; 9: 1377-1389). In the present study, we asked the question whether and, if so, how this isolate responds to a sub-inhibitory challenge with the antibiotic imipenem. To answer this question, we applied a SILAC proteomics approach that allowed the quantification of changes in the relative abundance of bacterial protein in response to imipenem. The results show that the investigated E. cloacae isolate mounts a highly specific response to counteract the detrimental effects of imipenem.

2021-08-10 | PXD013412 | Pride

Enterobacter cloacae complex

Project description:Carbapenemase-producing Enterobacter cloacae complex WGS

| PRJDB6828 | ENA

Enterobacter cloacae complex sp.

Project description:Enterobacter cloacae complex sp. overview

| PRJNA492672 | ENA

Enterobacter cloacae complex

Project description:Enterobacter cloacae complex Genome sequencing and assembly

| PRJNA737181 | ENA

Enterobacter cloacae complex

Project description:Enterobacter cloacae complex Genome sequencing and assembly

| PRJNA846540 | ENA

Enterobacter cloacae complex

Project description:Enterobacter cloacae complex Genome sequencing and assembly

| PRJNA808678 | ENA

Enterobacter cloacae complex

Project description:Enterobacter cloacae complex genome sequencing and assembly

| PRJNA553677 | ENA

Cefazolin and Imipenem Enhance AmpC Expression and Resistance in NagZ-dependent manner in Enterobacter cloacae complex

Project description:Background: Enterobacter cloacae complex (ECC) is a common opportunistic pathogen and is responsible for causing various infections in humans. Owing to its inducible chromosomal AmpC β-lactamase (AmpC), ECC is inherently resistant to the 1st- and 2nd- generation cephalosporins. However, whether β-lactams antibiotics enhance ECC resistance remains unclear. Results: In this study, we found that subinhibitory concentrations (SICs) of cefazolin (CFZ) and imipenem (IMP) can advance the expression of AmpC and enhance its resistance towards β-lactams through NagZ in Enterobacter cloacae (EC). Further, AmpC manifested a substantial upregulation in EC in response to SICs of CFZ and IMP. In nagZ knockout EC (ΔnagZ), the resistance to β-lactam antibiotics was rather weakened and the effect of CFZ and IMP on AmpC induction was completely abrogated. NagZ ectopic expression can rescue the induction effects of CFZ and IMP on AmpC and increase ΔnagZ resistance. More importantly, CFZ and IMP have the potential to induce the expression of AmpR's target genes in a NagZ-dependent manner. Conclusions: Our findings suggest that NagZ is a critical determinant for CFZ and IMP to promote AmpC expression and resistance and that CFZ and IMP should be used with caution since they may aggravate ECC resistance. At the same time, this study further improves our understanding of resistance mechanisms in ECC.

2022-07-01 | GSE207144 | GEO

Enterobacter cloacae complex colonization

Project description:Surveillance of Enterobacter cloacae complex colonization

| PRJEB46479 | ENA