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Regulated sulfur sequestration promotes multicellularity during nutrient limitation (scRNA-Seq)

ABSTRACT: Regulated sulfur sequestration promotes multicellularity during nutrient limitation (scRNA-Seq)

PROVIDER: PRJNA688507 | ENA |

REPOSITORIES: ENA

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Regulated sulfur sequestration promotes multicellularity during nutrient limitation

Project description:Regulated sulfur sequestration promotes multicellularity during nutrient limitation

| PRJNA688505 | ENA

Regulated sulfur sequestration promotes multicellularity during nutrient limitation (scRNA-Seq)

Project description:Dictyostelium discoideum behavior depends on nutrients1. When sufficient food is present these amoebae exist in a unicellular state, but upon starvation they aggregate into a multicellular organism2,3. This unique biology makes D. discoideum an ideal model for investigating how fundamental metabolic pathways command cell differentiation and function. We show here that reactive oxygen species (ROS), generated as a consequence of nutrient limitation, lead to the sequestration of the amino acid cysteine in the antioxidant glutathione, limiting the use of its sulfur atom for processes such as protein translation and FeS cluster-containing enzyme activity that contribute to mitochondrial metabolism and cellular proliferation. Such regulated sulfur sequestration maintains D. discoideum in a non-proliferating state that paves the way for multicellular development. This new mechanism of ROS signaling highlights oxygen and sulfur as simple, early evolutionary signaling molecules dictating cell fate, with implications for responses to nutrient fluctuations in higher eukaryotes.

2021-02-24 | GSE164010 | GEO

Regulated sulfur sequestration promotes multicellularity during nutrient limitation (RNA-Seq)

2021-02-24 | GSE164009 | GEO

Regulated sulfur sequestration promotes multicellularity during nutrient limitation (RNA-Seq)

Project description:Regulated sulfur sequestration promotes multicellularity during nutrient limitation (RNA-Seq)

| PRJNA688508 | ENA

Sulfur sequestration promotes multicellularity during nutrient limitation.

Project description: Not available

| S-EPMC7969356 | biostudies-literature

Regulated sulfur sequestration promotes multicellularity during nutrient limitation

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-02-24 | GSE164011 | GEO

Expression data from shoots of Arabidopsis grown under sulfur limitation.

Project description:Sulfate in one essential nutrient for plants and its limitation is known to have a significant impact on plant growth and yield. In this study we performed global transcriptome analyses to investigate the responses to long term sulfate deficiency at the shoot level. The shoot global transcriptomic responses to sulfur deprivation.

2017-08-16 | GSE93048 | GEO

Expression data from roots of Arabidopsis grown under sulfur, iron or potassium limitation

Project description:Deprivation of mineral nutrients causes significant retardation of plant growth. This slow growth is assumed to be associated with both nutrient specific transcriptional responses and additionally with common transcription patterns. In this study we adjusted the external supply of iron, potassium and sulfur to cause a similar retardation of growth. Global transcriptome analyses were performed to investigate whether the growth limitation by the different nutrient deficiencies triggered specific or similar transcriptional responses. The global transcriptome responded specifically to sulfur, iron or potassium deprivation. Arabidopsis thaliana plants were grown hydroponically under short-day conditions (8h light / 16h dark cycles) under full nutrient supply or under the limitation of sulfur, iron or potassium. Arabidopsis root material was harvested when the plants reached the age of 7 weeks (from sowing) and used for RNA extraction and hybridization on Affymetrix microarrays. Four biological replicates from each condition were analyzed.

2016-07-21 | E-GEOD-77602 | biostudies-arrayexpress

Expression data from roots of Arabidopsis grown under sulfur, iron or potassium limitation

2016-07-21 | GSE77602 | GEO

Transcription profiling by array of yeast strain FY1679 homozygous for HO deletion by KanMX4 grown in a series of nutrient limited continuous cultures carbon, nitrogen, phosphorus and sulfur limitation to determine genes which are growth rate regulated and those which are nutrient specific regulated

Project description:S. cerevisiae strain FY1679 homozygous for HO deletion by KanMX4 was grown in a series of nutrient limited continuous cultures carbon, nitrogen, phosphorus and sulfur limitation to determine genes which are growth rate regulated and those which are nutrient specific regulated.

2007-05-02 | E-MEXP-115 | biostudies-arrayexpress

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