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Epigenetic and Transcriptional profiling of Influenza-specific memory B cells

ABSTRACT: Epigenetic and Transcriptional profiling of Influenza-specific memory B cells

PROVIDER: PRJNA689423 | ENA |

REPOSITORIES: ENA

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Epigenetic and Transcriptional profiling of Influenza-specific memory B cells

Project description:This study aimed to characterize the chromatin accessibility and transcriptional differences between influenza-specific murine memory B cells and naive B cells. Memory B cells were subdivided into those that expressed either an IgM or IgG B cell receptor (BCR). Using B cell tetramers, we FACS isolated influenza-specific cells 35 days post-PR8 infection and performed ATAC-seq and RNA-seq. This SuperSeries is composed of the SubSeries listed below.

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Project description:To determine the differences in gene expression between antigen-experienced memory B cells and naïve B cells, we isolated influenza-specific memory B cells expressing either IgG or IgM BCR and compared their transcriptomes to naive B cells using RNA-seq.

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Transcriptional control of influenza-specific CD4+ tissue-resident memory T cell generation

Project description:Tissue-resident memory T cells (TRM) are a non-circulating subset of memory that are maintained at sites of pathogen entry and mediate optimal protection against reinfection. Lung TRM can be generated in response to respiratory infection or vaccination, however, the molecular pathways involved in CD4+TRM establishment have not been defined. Here, we performed transcriptional profiling of influenza-specific lung CD4+TRM following influenza infection to identify pathways implicated in CD4+TRM generation and homeostasis. Lung CD4+TRM displayed a unique transcriptional profile distinct from spleen memory, including up-regulation of a gene network induced by the transcription factor IRF4, a known regulator of effector T cell differentiation.

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Project description:Long-lived, tissue-resident memory B cells (BRM) are established in the lungs of mice after pulmonary influenza infection. Influenza-specific BRM were localised within inducible bronchus-associated lymphoid tissues (iBALT) and displayed phenotypic and transcriptional signatures reminiscent of tissue-resident T cells, distinct from classical memory B cells in the blood or secondary lymphoid sites.

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Transcriptome profiling of influenza-specific memory CD8 T cells in the lung airways, lung parenchyma, and spleen

Project description:To examine differences in the transcriptome of resident memory CD8 T cells in the lung, influenza nucleoprotein-specific CD8 T cells from the airways , lung parenchyma, and spleen were FACS sorted and RNA isolated for RNA-seq.

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