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Sox8 reprograms ectoderm into ear vesicles and associated neurons [Lmx1aE1_rnaseq]

ABSTRACT: Sox8 reprograms ectoderm into ear vesicles and associated neurons [Lmx1aE1_rnaseq]

PROVIDER: PRJNA705997 | ENA |

REPOSITORIES: ENA

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Sox8 reprograms ectoderm into ear vesicles and associated neurons [Sox8OE_rnaseq]

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Sox8 reprograms ectoderm into ear vesicles and associated neurons [Sox8OE_rnaseq]

Project description:The vertebrate inner ear arises from a pool of progenitors with the potential to give rise to all the sense organs and cranial ganglia of the head1-6. Here we explore the molecular mechanisms that control ear specification from these progenitors. Using a multi-omics approach combined with loss-of-function experiments we identify a core transcriptional circuit that imparts ear identity, along with non-coding elements that integrate this information. This analysis places the transcription factor Sox8 at the top of the ear determination network. Introducing Sox8 into cranial ectoderm not only converts non-ear cells into ear progenitors, but also activates the cellular programmes for ear morphogenesis and neurogenesis. Thus, Sox8 emerges as a master regulator of ear identity and may be a key factor for sense organ cell reprogramming.

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