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YTHDF2 inhibits gastric cancer cell growth by regulating FOXC2 signaling pathway

ABSTRACT: YTHDF2 inhibits gastric cancer cell growth by regulating FOXC2 signaling pathway

PROVIDER: PRJNA713007 | ENA |

REPOSITORIES: ENA

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YTHDF2 inhibits gastric cancer cell growth by regulating FOXC2 signaling pathway

Project description:YTHDF2 inhibits gastric cancer cell growth by regulating FOXC2 signaling pathway

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YTHDF2 inhibits gastric cancer cell growth by regulating FOXC2 signaling pathway

Project description:We found that YTHDF2 has lower expression in GC tissues and GC cells, and promotes the growth, migration and invasion of GC cells. In addition, the analysis of clinical data found that the expression level of YTHDF2 was closely related to the stage of GC and the survival of patients with GC. RNA-seq showed that overexpression of YTHDF2 significantly reduced protein expression in the FOXC2 (Forkhead box protein C2, FOXC2) signaling pathway.

2021-01-28 | GSE162004 | GEO

YTHDF2 inhibits gastric cancer cell growth by regulating FOXC2 signaling pathway

Project description:we found that YTHDF2 has lower expression in GC tissues and GC cells, and promotes the growth, migration and invasion of GC cells. In addition, the analysis of clinical data found that the expression level of YTHDF2 was closely related to the stage of GC and the survival of patients with GC. RNA-seq showed that overexpression of YTHDF2 significantly reduced protein expression in the FOXC2 (Forkhead box protein C2, FOXC2) signaling pathway.

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Expression analysis of colorectal cancer cell line SW480 expressing FOXC2

Project description:Investigation of whole genome gene expression level changes in a colorectal cancer cell line SW480 expressing FOXC2, compared to the pBabe control cells. Genes associated with metastasis regulated by FOXC2 in colorectal cancer were analysed. The role of FOXC2 in breast cancer metastasis are further described in Mani SA, Yang J et al. Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. PNAS 2007; 104: 10069-10074 . A six chip study using total RNA recovered from three separate cultures of SW480/pBabe and three separate cultures of SW480/FOXC2. Each chip measures the expression level of 45033 genes from SW480/pBabe or SW480/FOXC2.

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FOXC2 knockdown in MDA-MB-231 cells

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HMLER cells expressing either FOXC2 or a vector control

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Microarray profiling of YTHDF2 deficient mouse oocytes

Project description:To study the role of the protein YTHDF2 during female gametogenesis, its gene was conditionally deleted in oocytes. Total RNA samples from YTHDF2 deficient GV and MII oocytes (and control oocytes) were subjected to array profiling.

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YTHDF2/m6A/NF-κB axis controls anti-tumor immunity by regulating intratumoral Tregs

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