Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Next Generation Sequencing of DIO Liver steatosis DMSO vs NCT (HNF4a agonist)

ABSTRACT: Next Generation Sequencing of DIO Liver steatosis DMSO vs NCT (HNF4a agonist)

PROVIDER: PRJNA722504 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Next Generation Sequencing of DIO Liver steatosis DMSO vs NCT (HNF4a agonist)

Project description:Mice rendered obese with high fat diet were treated by IP injection with N-trans caffeoyltyramine (NCT) (200 mg/kg bid) for 14 days, followed by harvesting of the liver for analysis, including RNA isolation.

2021-04-17 | GSE172234 | GEO

Next Generation Sequencing of DIO intestine DMSO vs NCT (HNF4a agonist)

Project description:Next Generation Sequencing of DIO intestine DMSO vs NCT (HNF4a agonist)

| PRJNA738950 | ENA

Next Generation Sequencing of DIO intestine DMSO vs NCT (HNF4a agonist)

2021-06-18 | GSE178435 | GEO

Next Generation Sequencing of T6PNE human pancreatic cell with DMSO vs NCT (HNF4a agonist) in palmitate

Project description:T6PNE human pancreatic cells were treated by DMSO or N-trans caffeoyltyramine (NCT) for 2 days with palmitate, followed by harvesting for RNA isolation.

2021-05-22 | GSE174848 | GEO

Next Generation Sequencing of T6PNE human pancreatic cell with DMSO vs NCT (HNF4a agonist) in palmitate

Project description:Next Generation Sequencing of T6PNE human pancreatic cell with DMSO vs NCT (HNF4a agonist) in palmitate

| PRJNA731905 | ENA

Hypothalamus of diet-induced obese (DIO) mice treated with celastrol or DMSO

Project description:Since leptin signaling in the hypothalamus is critical to regulate food intake and body weight, we investigated how celastrol alters the hypothalamic transcriptome of DIO mice. By doing this analysis, genes with potential relevance for celastrol-mediated leptin sensitization could be identified.

2018-12-27 | GSE124353 | GEO

Priestia megaterium NCT-2

Project description:Priestia megaterium NCT-2 Genome sequencing

| PRJNA82241 | ENA

Priestia megaterium NCT-2

Project description:Priestia megaterium NCT-2 Genome sequencing

| PRJNA493010 | ENA

The transcription factor Hepatocyte Nuclear Factor 4A acts in the intestine to promote white adipose tissue energy storage

Project description:HNF4A is a transcription factor that controls metabolic features of several endodermal epithelia. Using an intestinal conditional mouse model, here we demonstrate that HNF4A is not required for intestinal lipid metabolism per se, but unexpectedly influences whole body energy expenditure under diet-induced obesity (DIO). Deletion of intestinal HNF4A causes mice to become DIO-resistant with preference for fat as an energy substrate and energetic changes in association with white adipose tissue (WAT) beiging. Intestinal HNF4A is crucial for fat-induced release of glucose-dependent insulinotropic polypeptide (GIP), while reintroduction of a stabilized GIP analog rescues the DIO-resistance phenotype of the mutant mice. Our study provides evidence that intestinal HNF4A plays a non-redundant role in whole body lipid homeostasis and points to a novel non-cell-autonomous regulatory circuit for body fat management.

2021-12-21 | GSE189439 | GEO

Hnf4a regulated transcriptome

Project description:Hnf4a regulated transcriptome

| PRJNA574921 | ENA