Genomics

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LCDR maintains the integrity of lysosomal membrane by hnRNP K-stabilized LAPTM5 transcript and promotes cell survival


ABSTRACT: LCDR maintains the integrity of lysosomal membrane by hnRNP K-stabilized LAPTM5 transcript and promotes cell survival

PROVIDER: PRJNA727295 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR14421423_1.fastq.gz Fastqsanger.gz
SRR14421423_2.fastq.gz Fastqsanger.gz
SRR14421424_1.fastq.gz Fastqsanger.gz
SRR14421424_2.fastq.gz Fastqsanger.gz
SRR14421425_1.fastq.gz Fastqsanger.gz
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Publications

<i>LCDR</i> regulates the integrity of lysosomal membrane by hnRNP K-stabilized <i>LAPTM5</i> transcript and promotes cell survival.

Yang Xiwang X   Wen Ya Y   Liu Shaomin S   Duan Liqiang L   Liu Tongfeng T   Tong Zhou Z   Wang Zhuo Z   Gu Yinmin Y   Xi Yibo Y   Wang Xiaodong X   Luo Dingsan D   Zhang Ruobing R   Liu Yajuan Y   Wang Yang Y   Cheng Tianyou T   Jiang Siyuan S   Zhu Xiaofeng X   Yang Xiaohui X   Pan Yongbo Y   Cheng Shuwen S   Ye Qinong Q   Chen Jinfei J   Xu Xiaoding X   Gao Shan S  

Proceedings of the National Academy of Sciences of the United States of America 20220201 5


Lysosome plays important roles in cellular homeostasis, and its dysregulation contributes to tumor growth and survival. However, the understanding of regulation and the underlying mechanism of lysosome in cancer survival is incomplete. Here, we reveal a role for a histone acetylation-regulated long noncoding RNA termed <i>lysosome cell death regulator</i> (<i>LCDR</i>) in lung cancer cell survival, in which its knockdown promotes apoptosis. Mechanistically, <i>LCDR</i> binds to heterogenous nucl  ...[more]

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