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Genome expression profile for CD3+ T cells treated by nimodipine in EAU model

ABSTRACT: Genome expression profile for CD3+ T cells treated by nimodipine in EAU model

PROVIDER: PRJNA759424 | ENA |

REPOSITORIES: ENA

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Genome expression profile for CD3+ T cells treated by nimodipine in EAU model

Project description:Uveitis is a severe autoimmune disease characereized by retinal inflammation, whicn brings harms to the visual function of the patients. We found that nimodipine could protect annimals from experimental autoimmune uveitis. To further clarify the possible mechanism through which nimodipine exerted effect, we performed genomic expression profiling of CD3+ T cells in EAU model and nimodipine treated group.

2021-09-03 | GSE183165 | GEO

Proteome and (ox)PTP profile analysis of diabetic NOD mouse under single (anti-CD3) or combined (anti-CD3 + IL1RA) treatment

Project description:Type 1 diabetes (T1D) results from autoimmune destruction of β cells in the pancreas. Protein tyrosine phosphatases (PTPs) are candidate genes for T1D and play a key role in autoimmune disease development and β-cell function. Here, we assessed the global protein and individual PTP profile in the pancreas of diabetic NOD mice treated with anti-CD3 mAb and IL-1RA combination therapy. The treatment reversed hyperglycemia compared to the anti-CD3 alone control group. We observed enhanced expression of PTPN2, a T1D candidate gene, and endoplasmic reticulum (ER) chaperones in the islets from cured mice.

2022-11-10 | PXD025394 | Pride

Identification of miRNA expression profile CD3+T lymphocytes

Project description:Identification of miRNA expression profile CD3+T lymphocytes

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Identification of miRNA expression profile CD3+T lymphocytes

Project description:Identification of miRNA expression profile CD3+T lymphocytes

2018-02-14 | GSE110565 | GEO

Analysis of graft-infiltrating CD8+ T cell profile after CD3 antibody therapy

Project description:We performed a global gene expression analysis comparing intragraft tolerant CD8+ T cells from CD3 antibody-treated mice showing permanent islet graft survival to intra-graft effector CD8+ T cells isolated from untreated mice showing acute rejection of islet allografts. The objective was to emphasize the anergic profile of CD8+ T cells residing within the pancreatic islet allograft of mice rendered tolerant following CD3 antibody therapy.

2017-02-10 | GSE68208 | GEO

Differential expression of miRNA in control and CD3/CD28mAb-treated Jurkat cells

Project description:The cultured cell line Jurkat is frequently employed in studies of T cell function. Here we identified the microRNAs expressed in Jurkat cells in the presence and absence of CD3/CD28mAb treatment. Analyzed the expression of microRNAs extracted from untreated Jurkat cells as a control and Jurkat cells treated with CD3/CD28mAb.

2010-12-31 | E-GEOD-23430 | biostudies-arrayexpress

Expression data from T-cell Acute Lymphoblastic Leukemia (T-ALL) patient-derived xenograft treated with anti-CD3 mAb

Project description:T-cell acute lymphoblastic leukemia is a hematological malignancy treated by chemotherapy, with a poor prognosis. We have demonstrated that activation of the T cell receptor (TCR) by anti-CD3 antibodies has a potent anti-leukemic effect in patient-derived xenograft models (PDX) of T-ALL. Therefore, with this experiment, we aim to identify the molecular mechanisms underlying the anti-leukemic properties of the OKT3 anti-CD3 mAb in T-ALL PDX.

2024-03-19 | GSE240296 | GEO

Gene expression profile of CD4+ T-cells restimulated by anti-CD3 and anti-ICOS compared to anti-CD3 alone

Project description:Engagement of the ICOS receptor represents a key event in a process that culminates in Bcl6 expression and acquisition of the TFH and TFR phenotype. To better understand the essentials of ICOS-mediated signaling pathway, we profiled the changes in gene expression elicited after co-ligation of ICOS and CD3 compared with CD3 ligation alone.

2014-09-23 | GSE61284 | GEO

BKM120 Treated WHIMs_17 Model Cohort

Project description:BKM120 Treated WHIMs_17 Model Cohort

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Transcriptomic profile of single-cell sorted monocytes, T cells and CD3+CD14+ cells from one subject infected with latent tuberculosis

Project description:We set out to detect a transcriptional signature in CD4 T cells of individuals at risk of progression to active tuberculosis. We indeed found such a signature which surprisingly could be tracked to a cell population expressing both T cell (CD3) and monocyte (CD14) markers. To identify the nature of the CD3+CD14+ population, we determined the transciptomic profile of single cells CD3-CD14+ Monocytes (n=21), CD3+D14- T cells (n=22), CD3+CD14+ cells in the Monocyte gate (Mgate) (n=22) and CD3+CD14+ cells in the lymphocyte gate (Lgate) (n=20) from one subject infected with latent tuberculosis by RNA sequencing. PCA on all genes showed that CD3+CD14+ cells represent an intermediate population between Monocytes and T cells, with CD3+CD14+ L gate cells closer to T cells compared to CD3+CD14+ Mgate cells.

2021-07-08 | GSE117435 | GEO

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