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Susceptibility loci for IgA nephropathy

ABSTRACT: Susceptibility loci for IgA nephropathy

PROVIDER: PRJNA80299 | ENA |

REPOSITORIES: ENA

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Expression data from human with IgA nephropathy (IgAN)

Project description:This SuperSeries is composed of the following subset Series: GSE35487: Expression data from human with IgA nephropathy (IgAN) [HG-U133A] GSE35488: Expression data from human with IgA nephropathy (IgAN) [HG-U133A_ENTREZG_10] Refer to individual Series

2012-02-02 | E-GEOD-35489 | biostudies-arrayexpress

Micro RNA expression profiling using NanoString technology from IgA Nephropathy patients from Indian cohort.

Project description:The current study makes use of NanoString targeted technology to profile urinary exosomal miRNAs from IgA nephropathy affected patients and corresponding healthy controls. Circulatory biomarkers were detected for IgA nephropathy from Indian cohort which can be made used for the diagnostic therapy. 14 miRNAs were detected to be related to the disregulation in miRNome of IgA nephropathy patients using lasso feature selection method, out of which multiple miRNAs like hsa.mir.146b.3p, hsa.mir.599 and many more was resulted with high AUROC values >=0.9 efficient in differentiating between healthy controls and IgA nephropathy condition. These markers can be use further in the diagnosis and treatment of IgAN.

2023-12-13 | GSE244625 | GEO

Single-cell RNAseq analysis of kidney glomerular injury in IgA nephropathy

Project description:We applied scRNAseq analysis to investigate the mouse kidney glomerular injury in IgA nephropathy

2022-02-01 | GSE166793 | GEO

The role of microRNAs in the pathogenesis of IgA nephropathy

Project description:We report the expression of microRNAs in renal biopsies from patients with IgA nephropathy (progressive form and non progressive form), membranous and thin membrane nephropathies

2021-02-23 | GSE141344 | GEO

Specific biomarkers Associated with Active and Chronic Renal Lesions in IgA Nephropathy. A Multicenter Study

Project description:Specific molecular biomarkers were detected in kidney biopsy of IgA nephropathy characterizing active (E and C) and chronic (T) renal lesions compared with other non-IgA glomerulonephritis and living donors

2020-09-13 | GSE116626 | GEO

Homo sapiens

Project description:Susceptibility loci for IgA nephropathy

| PRJNA80301 | ENA

A partial picture of the single-cell transcriptomics of human IgA nephropathy

Project description:The comprehensive analysis of kidney biopsy specimen demonstrated different gene expression profile, potential pathologic ligand-receptor crosstalk, signaling pathways in human IgAN. These results offer new insight into pathogenesis and identify new therapeutic targets for patients with IgA nephropathy.

2021-04-02 | GSE171314 | GEO

Single-cell RNA-seq profiling reveals novel insights in immune-complex deposition and epithelium transition in IgA nephropathy

Project description:IgA nephropathy represents the most prevalent chronic nephrosis worldwide. However, pathogenesis about IgA deposition and end-stage renal failure is still not well defined. Using single-cell RNA-seq, we identified the mesangial membrane receptor for IgA, which collaborates with increased extracellular matrix proteins and protease inhibitor to facilitate IgA deposition. Meanwhile, cell-cell interaction analysis revealed increased communications between mesangium and other cell types, uncovering how morbidity inside glomerulus spreads to whole kidney, which results in the genetic changes of kidney resident immune cells. Prominent interaction decreasing in intercalated cells leads to the discovery of a transitional cell type, which exhibited significant EMT and fibrosis features. Our work comprehensively characterized the pathological mesangial signatures, highlighting the step-by-step pathogenic process of IgA nephropathy from mesangium to epithelium.

2021-07-06 | GSE127136 | GEO

Role of IgG autoantibodies in the pathogenesis of IgA nephropathy assessed in a passive mouse model

Project description:IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, is characterized by IgA1-containing glomerular immunodeposits. These immunodeposits are thought to originate from the circulating immune complexes consisting of aberrantly glycosylated IgA1 (galactose-deficient IgA1; Gd-IgA1) bound by IgG autoantibodies. This hypothesis is supported by the findings that renal immunodeposits of IgA nephropathy patients are enriched for IgG autoantibodies specific for galactose-deficient IgA1 (Rizk et al., J. Am. Soc. Nephrol. 30(10), 2017-2026, 2019). However, experimental proof is needed. This study provides in vivo data in mice that support the pathogenic role of IgG autoantibodies in IgAN.

2021-01-31 | GSE156179 | GEO

IgA Nephropathy GWAS (IGANGWAS)

Project description:<p>We report a genome-wide association study of IgA nephropathy, a main cause of kidney failure. All subjects were of Chinese Han ancestry, of which 1,194 were cases and 902 controls. Genomic DNA samples extracted from whole blood were genotyped on the Illumina 610 Quad platform.</p>

| phs000431.v1.p1 | EGA

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