Candida albicans
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA95737 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Eighteen hours monoclonal antibody C7 exposure
| PRJNA135441 | ENA
Project description:N2 young adult animals were analyzed four hours after exposure to wild-type Candida albicans DAY185, heat-killed C. albicans DAY185 and heat-killed Escherichia coli OP50, all on Brain Heart Infusion (BHI) agar. It was necessary to use heat-killed E. coli OP50 as a control for these experiments because live E. coli OP50 (the normal nematode food source) is pathogenic to nematodes on BHI agar. These data identify the C. elegans genes that are differentially regulated during nematode infection with a human fungal pathogen.
2011-06-04 | GSE27401 | GEO
Project description:Given the risk of Candida albicans overgrowth in the gut, novel complementary therapies should be developed to reduce fungal dominancy. This study highlights the antifungal characteristics of a Bacillus subtilis-derived secondary metabolite, surfactin with high potential against C. albicans. Surfactin inhibited the growth of C. albicans following a 1-hour exposure, in addition to reduced adhesion and morphogenesis. Specifically, surfactin did not affect the level of reactive oxygen species but increased the level of reduced glutathione. Surprisingly, ethanol production was increased following 2 hours of surfactin exposure. Surfactin treatment caused a significant reduction in intracellular iron, manganese and zinc content compared to control cells, whereas the level of copper was not affected. Alongside these physiological properties, surfactin also enhanced fluconazole efficacy. To gain detailed insights into the surfactin-related effects on C. albicans, genome-wide gene transcription analysis was performed. Surfactin treatment resulted in 1390 differentially expressed genes according to total transcriptome sequencing (RNA-Seq). Of these, 773 and 617 genes with at least a 1.5-fold increase or decrease in transcription, respectively, were selected for detailed investigation. Several genes involved in morphogenesis or related to metabolism (e.g., glycolysis, ethanol and fatty acid biosynthesis) were down-regulated. Moreover, surfactin decreased the expression of ERG1, ERG3, ERG9, ERG10 and ERG11 involved in ergosterol synthesis, whereas genes associated with ribosome biogenesis and iron metabolism and drug transport-related genes were up-regulated. Our data demonstrate that surfactin significantly influences the physiology and gene transcription of C. albicans, and could contribute to the development of a novel innovative complementary therapy.
2022-06-02 | GSE199383 | GEO
Project description:Genes Differentially Expressed as a result of Candida albicans SC5314 exposure to 10b
| PRJNA122389 | ENA
Project description:Genes differentially expressed as a result of Candida albicans SC5314 exposure to pterostilbene
| PRJNA187062 | ENA
Project description:Genes Differentially Expressed as a result of Candida albicans SC5314 biofilms exposure to 10b
| PRJNA120851 | ENA
Project description:To elucidate the impact of IFU5 in Candida albicans, genome wide transcription profiling was performed in ifu5?/? mutant strain. Wild type and mutant cells were grown for 5 hours and RNA extracted from these cultures, followed by microarray profiling. Expression of six genes (EFG1, ALS3, SOD3, BMT4, COX2, NAD1) was validated by qPCR.
2019-02-01 | GSE110650 | GEO
Project description:To infer transcriptional networks of nitrogen utilization , Candida albicans was exposed to nitrogen starvation for four hours and then offered arginine or BSA as sole nitrogen source. Time-series transcription data was obtained from both the starvation and the feeding periods, and the response to different nitrogen availability was used for network modelling with selected genes.
2014-04-02 | E-MTAB-2171 | biostudies-arrayexpress
Project description:Transcriptional profiling of Candida albicans that had been phagocytosed for 1, 2, or 4 hours by either bone marrow-derived mouse macrophaged (BMDM) or immortalized RAW264.7 cells Keywords: Time course
2008-07-28 | GSE11399 | GEO
Project description: Not available
| S-EPMC1951527 | biostudies-literature