Dataset Information
Mm_Stem_cell_dimethyl_ETD
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA155475PRJNA150567PRJNA153541PRJNA156463
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus
SUBMITTER: Albert J. R. Heck
PROVIDER: PAe003968 | PeptideAtlas | 2012-12-31
REPOSITORIES: PeptideAtlas
Publications
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.
The EMBO journal 20120612 14
Two types of stem cells are currently defined in small intestinal crypts: cycling crypt base columnar (CBC) cells and quiescent '+4' cells. Here, we combine transcriptomics with proteomics to define a definitive molecular signature for Lgr5(+) CBC cells. Transcriptional profiling of FACS-sorted Lgr5(+) stem cells and their daughters using two microarray platforms revealed an mRNA stem cell signature of 384 unique genes. Quantitative mass spectrometry on the same cell populations identified 278 p ...[more]
