Proteomics

Dataset Information

0

HapMap_LCL_TMT_quant_2


ABSTRACT: Variation and genetic control of protein abundance in humans, 2

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Others

SUBMITTER: Wu L, Candille SI, Choi Y, Xie D, Jiang L, Li-Pook-Than J, Tang H, Snyder M 

PROVIDER: PAe005077 | PeptideAtlas | 2013-12-31

REPOSITORIES: PeptideAtlas

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Publications

Variation and genetic control of protein abundance in humans.

Wu Linfeng L   Candille Sophie I SI   Choi Yoonha Y   Xie Dan D   Jiang Lihua L   Li-Pook-Than Jennifer J   Tang Hua H   Snyder Michael M  

Nature 20130515 7456


Gene expression differs among individuals and populations and is thought to be a major determinant of phenotypic variation. Although variation and genetic loci responsible for RNA expression levels have been analysed extensively in human populations, our knowledge is limited regarding the differences in human protein abundance and the genetic basis for this difference. Variation in messenger RNA expression is not a perfect surrogate for protein expression because the latter is influenced by an a  ...[more]

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