Dataset Information

Ovarian_Cancer_iTRAQ_PNNL_1

ABSTRACT: TCGA Cancer Proteome Study of Ovarian Tissue, iTRAQ, PNNL, part 1

OTHER RELATED OMICS DATASETS IN: MSV000084252PRJNA225826phs000178.v6.p6

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Female Reproductive System

SUBMITTER: Bell D, et al.

PROVIDER: PAe005192 | PeptideAtlas | 2011-12-31

REPOSITORIES: PeptideAtlas

ACCESS DATA

Publications

Integrated genomic analyses of ovarian carcinoma.

Nature 20110629 7353

A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients' lives. The Cancer Genome Atlas project has analysed messenger RNA expression, microRNA expression, promoter methylation and DNA copy number in 489 high-grade serous ovarian adenocarcinomas and the DNA sequences of exons from coding genes in 316 of these tumours. Here we report that high-grade serous ovarian cancer is characterized by TP53 mutations in almo ...[more]

PMID: 21720365

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Project description:<a href="https://pdc.esacinc.com/pdc/browse/filters/study_name:TCGA_Ovarian_JHU_Glycoproteome|TCGA_Ovarian_JHU_Proteome|TCGA_Ovarian_PNNL_Proteome|TCGA_Ovarian_PNNL_Phosphoproteome_Velos_Qexatvive">Explore This Study at the NCI Proteomic Data Commons</a> Global proteome data have been acquired for 174 TCGA ovarian cancer tumor samples by 2 Proteome Characterization Centers (PCCs), Pacific Northwest National Laboratory (PNNL) and Johns Hopkins University (JHU). Both PCCs used iTRAQ (isobaric Tags for Relative and Absolute Quantification) protein quantification methods. Thirty-two of the 174 TCGA tumor samples were assayed at both sites yielding a total of 206 proteome characterizations. Glycoproteome (122 tumors) and phosphoproteome (69 tumors) analyses were also conducted, at JHU and PNNL respectively. Information on the complete TCGA Ovarian Serous Cystadenocarcinoma (OV) cohort can be found <a href="https://portal.gdc.cancer.gov/projects/TCGA-OV">here</a>. The Cancer Genome Atlas Research Network published on the Genomic characterization of the OV cohort in <a href="https://www.ncbi.nlm.nih.gov/pubmed/21720365">Nature</a> on June 30, 2011 Genomic data for the 174 TCGA samples used in the CPTAC Proteome study can be downloaded from <a href="https://portal.gdc.cancer.gov/legacy-archive/search/f?filters=%7B%22op%22:%22and%22,%22content%22:%5B%7B%22op%22:%22in%22,%22content%22:%7B%22field%22:%22cases.project.program.name%22,%22value%22:%5B%22TCGA%22%5D%7D%7D,%7B%22op%22:%22in%22,%22content%22:%7B%22field%22:%22cases.project.project_id%22,%22value%22:%5B%22TCGA-OV%22%5D%7D%7D%5D%7D">here</a>.<ul><li>Dataset imported into MassIVE from <a href="https://cptac-data-portal.georgetown.edu/cptac/s/S020">https://cptac-data-portal.georgetown.edu/cptac/s/S020</a> on 08/26/19</li><li>Dataset source: <a href="https://pdc.esacinc.com/pdc/browse/filters/study_name:TCGA_Ovarian_JHU_Glycoproteome%7CTCGA_Ovarian_JHU_Proteome%7CTCGA_Ovarian_PNNL_Proteome%7CTCGA_Ovarian_PNNL_Phosphoproteome_Velos_Qexatvive">https://pdc.esacinc.com/pdc/browse/filters/study_name:...</a></li></ul>

Dataset Information

Ovarian_Cancer_iTRAQ_PNNL_1

Publications

Integrated genomic analyses of ovarian carcinoma.

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