Proteomics

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Plasma Proteomic Profiling Identifies a Six-Protein Panel for Grading and Predicting Intervertebral Disc Degeneration

ABSTRACT: In order to identify and validate specific plasma proteins associated with varying grades of intervertebral disc degeneration. By establishing a panel of potential biomarkers, this research seeks to enhance diagnostic accuracy and provide insights into the biological processes underlying IDD.A case-control design was employed, involving a cohort of patients diagnosed with different grades of IDD. A comparative analysis of plasma samples from patients with grade II and grade V degeneration was conducted, allowing for the assessment of differential protein expression. A total of 6,345 human plasma proteins targets were evaluated by SomaScan Assay, yielding 208 proteins with statistically significant differential expression between grade II and grade V IDD patients. Further analysis revealed that among these differentially expressed proteins, 107 were significantly upregulated, while 101 were significantly downregulated in grade V patients.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Bone Marrow

SUBMITTER: Jingzi Zhang  

LAB HEAD: ZHANG Jingzi

PROVIDER: PAD000013 | Pride | 2025-12-04

REPOSITORIES: Pride

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NJDX.hybNorm.medNormInt.plateScale.calibrate.anmlQC.qcCheck.anmlSMP.adat Other
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Plasma Proteomic Profiling Identifies a Six-Protein Panel for Grading and Predicting Intervertebral Disc Degeneration.

Zhou Ziyue Z   Li Yinkun Y   Zhu Lin L   Li Hui H   Wang Nannan N   Zhou Haiyuan H   Zhang Jingzi J   Fang Lei L   Li Sen S  

Journal of proteome research 20260123 2

Intervertebral disc degeneration (IDD) represents a significant health concern affecting a large portion of the population and leads to chronic pain and disability. Despite the prevalence of this condition, the underlying biological mechanisms and potential biomarkers for early diagnosis remain inadequately understood. Advances in proteomics have opened new avenues for identifying blood biomarkers that can facilitate better diagnostic and therapeutic strategies. The primary aim of this study was  ...[more]

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