Dataset Information
N-acetyltransferase A - Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q-Tof Premier, instrument model, Agilent instrument model
ORGANISM(S): Homo Sapiens (human) Saccharomyces Cerevisiae (baker's Yeast)
TISSUE(S): Yeast
DISEASE(S): Cervix Carcinoma
SUBMITTER: 
Petra Van Damme
PROVIDER: PRD000075 | Pride | 2009-07-28
REPOSITORIES: Pride
Publications
Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans.
Proceedings of the National Academy of Sciences of the United States of America 20090506 20
N(alpha)-terminal acetylation is one of the most common protein modifications in eukaryotes. The COmbined FRActional DIagonal Chromatography (COFRADIC) proteomics technology that can be specifically used to isolate N-terminal peptides was used to determine the N-terminal acetylation status of 742 human and 379 yeast protein N termini, representing the largest eukaryotic dataset of N-terminal acetylation. The major N-terminal acetyltransferase (NAT), NatA, acts on subclasses of proteins with Ser- ...[more]
