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Bacillithiolation and hypochlorite resistance

ABSTRACT: cytoplasmic extract of Bacillus subtilis wild type control (untreated) separated by non-reducing SDS-PAGE, lane cut into 10 fractions, fraction 1 in-gel-digested

OTHER RELATED OMICS DATASETS IN: PRJNA138515

INSTRUMENT(S): LTQ-Orbitrap

ORGANISM(S): Bacillus Subtilis Subsp. Subtilis Str. 168

SUBMITTER: Haike Antelmann

LAB HEAD: Haike Antelmann

PROVIDER: PRD000439 | Pride | 2011-08-01

REPOSITORIES: Pride

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			Action	DRS
	PRIDE_Exp_Complete_Ac_17516.pride.mgf.gz	Mgf
	PRIDE_Exp_Complete_Ac_17516.pride.mztab.gz	Mztab
	PRIDE_Exp_Complete_Ac_17516.xml.gz	Xml
	PRIDE_Exp_Complete_Ac_17517.pride.mgf.gz	Mgf
	PRIDE_Exp_Complete_Ac_17517.pride.mztab.gz	Mztab

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Publications

S-bacillithiolation protects against hypochlorite stress in Bacillus subtilis as revealed by transcriptomics and redox proteomics.

Chi Bui Khanh BK Gronau Katrin K Mäder Ulrike U Hessling Bernd B Becher Dörte D Antelmann Haike H

Molecular & cellular proteomics : MCP 20110711 11

Protein S-thiolation is a post-translational thiol-modification that controls redox-sensing transcription factors and protects active site cysteine residues against irreversible oxidation. In Bacillus subtilis the MarR-type repressor OhrR was shown to sense organic hydroperoxides via formation of mixed disulfides with the redox buffer bacillithiol (Cys-GlcN-Malate, BSH), termed as S-bacillithiolation. Here we have studied changes in the transcriptome and redox proteome caused by the strong oxida ...[more]

PMID: 21749987

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