Ontology highlight
ABSTRACT:
INSTRUMENT(S): instrument model, LTQ Velos
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Adam Byron
PROVIDER: PXD000155 | Pride | 2015-01-26
REPOSITORIES: Pride
Byron Adam A Askari Janet A JA Humphries Jonathan D JD Jacquemet Guillaume G Koper Ewa J EJ Warwood Stacey S Choi Colin K CK Stroud Matthew J MJ Chen Christopher S CS Knight David D Humphries Martin J MJ
Nature communications 20150122
Integrin activation, which is regulated by allosteric changes in receptor conformation, enables cellular responses to the chemical, mechanical and topological features of the extracellular microenvironment. A global view of how activation state converts the molecular composition of the region proximal to integrins into functional readouts is, however, lacking. Here, using conformation-specific monoclonal antibodies, we report the isolation of integrin activation state-dependent complexes and the ...[more]