Proteomic analysis of yeast mutant RNA exosome complexes
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q-Tof Premier, instrument model
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: 
Rogerio Lourenço
PROVIDER: PXD000580 | Pride | 2014-04-15
REPOSITORIES: Pride
Publications
Proteomic analysis of yeast mutant RNA exosome complexes.
Lourenço Rogério F RF Leme Adriana F P AF Oliveira Carla C CC
Journal of proteome research 20131126 12
The yeast exosome is a conserved multiprotein complex essential for RNA processing and degradation. The complex is formed by a nine-subunit core that associates with two hydrolytic 3'-5' exoribonucleases. Although catalytically inert, the assembly of this nine-subunit core seems to be essential for the exosome activity, as mutations in regions that do not directly bind RNA or are not in the active sites of the exonucleases impair the function of the complex. Previously isolated mutations in the ...[more]
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