Proteomics

Dataset Information

64

MDA-MB-231 Breast Cancer Bone Tropic vs Parental Hypoxic Secretome Analysis


ABSTRACT: The project profiled the expression patterns in hypoxia induced secretomes between MDA-MB-231 parental and MDA-MB-231 Bone Tropic (BT) breast cancer cell lines which have been previously generated by Massague and colleagues (Kang et al. Cancer Cell 2003).

REANALYSED by: GPM32310020157

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo sapiens  

TISSUE(S): Tissue Not Applicable To Dataset

DISEASE(S): Not Available

SUBMITTER: Thomas Cox  

LAB HEAD: Janine T Erler

PROVIDER: PXD000397 | Pride | 2015-05-28

REPOSITORIES: Pride

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Publications


Tumour metastasis is a complex process involving reciprocal interplay between cancer cells and host stroma at both primary and secondary sites, and is strongly influenced by microenvironmental factors such as hypoxia. Tumour-secreted proteins play a crucial role in these interactions and present strategic therapeutic potential. Metastasis of breast cancer to the bone affects approximately 85% of patients with advanced disease and renders them largely untreatable. Specifically, osteolytic bone le  ...[more]

Publication: 1/2

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