Erythrocyte Proteome & Terminome
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Philipp Lange
PROVIDER: PXD000434 | Pride | 2014-02-24
REPOSITORIES: Pride
Publications
Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome.
Lange Philipp F PF Huesgen Pitter F PF Nguyen Karen K Overall Christopher M CM
Journal of proteome research 20140310 4
A goal of the Chromosome-centric Human Proteome Project is to identify all human protein species. With 3844 proteins annotated as "missing", this is challenging. Moreover, proteolytic processing generates new protein species with characteristic neo-N termini that are frequently accompanied by altered half-lives, function, interactions, and location. Enucleated and largely void of internal membranes and organelles, erythrocytes are simple yet proteomically challenging cells due to the high hemogl ...[more]
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