Ontology highlight
ABSTRACT:
INSTRUMENT(S): instrument model
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): T Cell, Blood
SUBMITTER: Hannah Johnson
PROVIDER: PXD000440 | Pride | 2013-11-07
REPOSITORIES: Pride
Arneja Abhinav A Johnson Hannah H Gabrovsek Laura L Lauffenburger Douglas A DA White Forest M FM
Journal of immunology (Baltimore, Md. : 1950) 20131202 1
IL-2 and IL-15 are common γ-chain family cytokines involved in regulation of T cell differentiation and homeostasis. Despite signaling through the same receptors, IL-2 and IL-15 have non-redundant roles in T cell biology, both physiologically and at the cellular level. The mechanisms by which IL-2 and IL-15 trigger distinct phenotypes in T cells remain elusive. To elucidate these mechanisms, we performed a quantitative comparison of the phosphotyrosine signaling network and resulting phenotypes ...[more]