Human CDK Family - Proteomic Analysis of the Human CDK Family Reveals a Novel CDK5 Complex Involved in Cell Growth and Migration

ABSTRACT: Cyclin-dependent kinases (Cdks) are the catalytic subunits of a family of mammalian heterodimeric serine/threonine kinases that play critical roles in control of cell-cycle progression, transcription and neuronal functions. To systematically investigate the regulations and functions of CDKs, we conducted a proteomic analysis of human CDK family and identified their associated protein complexes in two different cell lines using a modified SAINT (Significance Analysis of INTeractome) method. We discovered 753 HCIPs (high-confidence candidate interaction proteins) in HEK293T cells and 352 HCIPs in MCF10A cells.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Mcf-10a Cell, Permanent Cell Line Cell, Hek-293t Cell

SUBMITTER: Xu Li  

LAB HEAD: Junjie Chen

PROVIDER: PXD000593 | Pride | 2014-08-08

REPOSITORIES: Pride