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Comparative Exoprotein Profiling of Different Staphylococcus epidermidis strains Reveals Potential Link between Non-classical Protein Export and Virulence

ABSTRACT: This study reports global exoproteome profiling of bovine mastitis strain PM221 and two human strains, commensal-type ATCC12228 and sepsis-associated RP62A to screen for factors underlying adaptation and virulence.

INSTRUMENT(S): QSTAR

ORGANISM(S): Staphylococcus Epidermidis

SUBMITTER: Pia SiljamÃ¤ki

LAB HEAD: Tuula A Nyman

PROVIDER: PXD000631 | Pride | 2014-06-04

REPOSITORIES: Pride

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Comparative exoprotein profiling of different Staphylococcus epidermidis strains reveals potential link between nonclassical protein export and virulence.

Siljamäki Pia P Varmanen Pekka P Kankainen Matti M Sukura Antti A Savijoki Kirsi K Nyman Tuula A TA

Journal of proteome research 20140602 7

Staphylococcus epidermidis (SE) includes commensal and pathogenic strains capable of infecting humans and animals. This study reports global exoproteome profiling of bovine mastitis strain PM221 and two human strains, commensal-type ATCC12228 and sepsis-associated RP62A. We identified 451, 395, and 518 proteins from culture supernatants of PM221, ATCC12228, and RP62A, respectively. Comparison of the identified exoproteomes revealed several strain-specific differences related to secreted antigens ...[more]

PMID: 24840314

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