Dataset Information

Rat Brain LC-MS/MS - Quantitative Proteomics Reveals Protein-Protein Interactions with Fibroblast Growth Factor12 as a Component of the Nav1

ABSTRACT: Voltage-gated sodium channels are responsible for the initiation and propagation of action potentials in excitable cells. While the channel is functional on its own, it is the transient and stable protein-protein interactions that modulate functional outcomes. AP-MS has been successfully applied to a number of ion channels. However to the best of our knowledge, no AP-MS study has been carried out on any member of the voltage-gated sodium channel family.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain, Electrically Active Cell

SUBMITTER: Norelle Wildburger

LAB HEAD: Carol Lynn Nilsson

PROVIDER: PXD000719 | Pride | 2015-03-03

REPOSITORIES: Pride

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Publications

Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain.

Wildburger Norelle C NC Ali Syed R SR Hsu Wei-Chun J WC Shavkunov Alexander S AS Nenov Miroslav N MN Lichti Cheryl F CF LeDuc Richard D RD Mostovenko Ekaterina E Panova-Elektronova Neli I NI Emmett Mark R MR Nilsson Carol L CL Laezza Fernanda F

Molecular & cellular proteomics : MCP 20150227 5

Voltage-gated sodium channels (Nav1.1-Nav1.9) are responsible for the initiation and propagation of action potentials in neurons, controlling firing patterns, synaptic transmission and plasticity of the brain circuit. Yet, it is the protein-protein interactions of the macromolecular complex that exert diverse modulatory actions on the channel, dictating its ultimate functional outcome. Despite the fundamental role of Nav channels in the brain, information on its proteome is still lacking. Here w ...[more]

PMID: 25724910

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Dataset Information

Rat Brain LC-MS/MS - Quantitative Proteomics Reveals Protein-Protein Interactions with Fibroblast Growth Factor12 as a Component of the Nav1

Publications

Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain.

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