Transcription profiling of mouse neuroblastoma cells transfected with CCAT to investigate CCAT regulated gene expression

ABSTRACT: Voltage gated calcium channels play a central role in regulating the electrical and biochemical properties of neurons and muscle cells. Cells coordinate the expression of voltage gated calcium channels with the expression of other proteins that regulate membrane potential and calcium homeostasis. We report that the C-terminus of CaV 1.2, an L-type calcium channel (LTC) contains a C-terminal fragment that translocates to the nucleus and regulates transcription. This calcium channel associated transcription factor (CCAT) associates with transcriptional co-regulators such as p54nrb/NonO and binds to endogenous promoters. CCAT regulates the expression of gap junctions, sodium calcium exchangers, NMDA receptors, potassium channels and other proteins that regulate neuronal signaling. Electr

ORGANISM(S): Mus musculus

SUBMITTER: Ricardo Dolmetsch 

PROVIDER: E-GEOD-4180 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress