Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver
SUBMITTER: Bing Qing Liao
LAB HEAD: Carsten Schmitz-Peiffer
PROVIDER: PXD000971 | Pride | 2014-11-04
REPOSITORIES: Pride
Liao Bing M BM Raddatz Katy K Zhong Ling L Parker Benjamin L BL Raftery Mark J MJ Schmitz-Peiffer Carsten C
Proteomics 20141014 21-22
Insulin resistance contributes to the development of Type 2 diabetes, and is associated with lipid oversupply. Deletion of isoforms of the lipid-activated protein kinase C (PKC) family, PKCδ or PKCε, improves insulin action in fat-fed mice, but differentially affects hepatic lipid metabolism. To investigate the mechanisms involved, we employed an in vivo adaptation of SILAC to examine the effects of a fat diet together with deletion of PKCδ or PKCε on the expression of liver proteins. We identif ...[more]