Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap, Q TRAP
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Hepatocyte
SUBMITTER: David Campbell
LAB HEAD: Kei Sakamoto
PROVIDER: PXD001032 | Pride | 2014-08-08
REPOSITORIES: Pride
Patel Kashyap K Foretz Marc M Marion Allison A Campbell David G DG Gourlay Robert R Boudaba Nadia N Tournier Emilie E Titchenell Paul P Peggie Mark M Deak Maria M Wan Min M Kaestner Klaus H KH Göransson Olga O Viollet Benoit B Gray Nathanael S NS Birnbaum Morris J MJ Sutherland Calum C Sakamoto Kei K
Nature communications 20140804
LKB1 is a master kinase that regulates metabolism and growth through adenosine monophosphate-activated protein kinase (AMPK) and 12 other closely related kinases. Liver-specific ablation of LKB1 causes increased glucose production in hepatocytes in vitro and hyperglycaemia in fasting mice in vivo. Here we report that the salt-inducible kinases (SIK1, 2 and 3), members of the AMPK-related kinase family, play a key role as gluconeogenic suppressors downstream of LKB1 in the liver. The selective SI ...[more]