Ontology highlight
ABSTRACT:
INSTRUMENT(S): TOF/TOF 5800
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain, Neuron, Hippocampus
SUBMITTER: Pim van Nierop
LAB HEAD: Dr. Ronald van Kesteren
PROVIDER: PXD001135 | Pride | 2014-09-10
REPOSITORIES: Pride
Végh Marlene J MJ Rausell Antonio A Loos Maarten M Heldring Céline M CM Jurkowski Wiktor W van Nierop Pim P Paliukhovich Iryna I Li Ka Wan KW del Sol Antonio A Smit August B AB Spijker Sabine S van Kesteren Ronald E RE
Molecular & cellular proteomics : MCP 20140720 11
Age-related cognitive decline is a serious health concern in our aging society. Decreased cognitive function observed during healthy brain aging is most likely caused by changes in brain connectivity and synaptic dysfunction in particular brain regions. Here we show that aged C57BL/6J wild-type mice have hippocampus-dependent spatial memory impairments. To identify the molecular mechanisms that are relevant to these memory deficits, we investigated the temporal profile of mouse hippocampal synap ...[more]