Impacts of 2-amino-4,6-dinitrotoluene (2-ADNT) Exposure in Northern Bobwhite
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA257048
INSTRUMENT(S): LCQ Deca XP Plus
ORGANISM(S): Colinus Virginianus (northern Bobwhite) (tetrao Virginianus)
TISSUE(S): Liver, Kidney
SUBMITTER: 
Ken Pendarvis
LAB HEAD: Kurt A. Gust
PROVIDER: PXD001206 | Pride | 2016-07-06
REPOSITORIES: Pride
Publications
Systems toxicology identifies mechanistic impacts of 2-amino-4,6-dinitrotoluene (2A-DNT) exposure in Northern Bobwhite.
Gust Kurt A KA Nanduri Bindu B Rawat Arun A Wilbanks Mitchell S MS Ang Choo Yaw CY Johnson David R DR Pendarvis Ken K Chen Xianfeng X Quinn Michael J MJ Johnson Mark S MS Burgess Shane C SC Perkins Edward J EJ
BMC genomics 20150807
<h4>Background</h4>A systems toxicology investigation comparing and integrating transcriptomic and proteomic results was conducted to develop holistic effects characterizations for the wildlife bird model, Northern bobwhite (Colinus virginianus) dosed with the explosives degradation product 2-amino-4,6-dinitrotoluene (2A-DNT). A subchronic 60 d toxicology bioassay was leveraged where both sexes were dosed via daily gavage with 0, 3, 14, or 30 mg/kg-d 2A-DNT. Effects on global transcript expressi ...[more]
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