Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Donald Wolfgeher
LAB HEAD: Stephen J. Kron
PROVIDER: PXD001284 | Pride | 2014-12-08
REPOSITORIES: Pride
Journal of proteomics 20141018
The highly conserved molecular chaperones Hsp90 and Hsp70 are indispensible for folding and maturation of a significant fraction of the proteome, including many proteins involved in signal transduction and stress response. To examine the dynamics of chaperone-client interactions after DNA damage, we applied quantitative affinity-purification mass spectrometry (AP-MS) proteomics to characterize interactomes of the yeast Hsp70 isoform Ssa1 and Hsp90 isoform Hsp82 before and after exposure to methy ...[more]