Dynamic metabolic reprogramming in dendritic cells: an early response to influenza infection that is essential for effector function

ABSTRACT: In response to influenza infection we found that dendritic cells (DCs), cells that are critical in mounting an effective immune response, undergo a profound metabolic shift. DCs alter the concentration and location of hundreds of proteins, including c-MYC, mediating a shift to a highly glycolytic phenotype that is also flexible in terms of fueling respiration.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lymph Node

SUBMITTER: Matthew Monroe  

LAB HEAD: Heather Smallwood

PROVIDER: PXD013690 | Pride | 2021-09-08

REPOSITORIES: Pride