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Dynamic metabolic reprogramming in dendritic cells: an early response to influenza infection that is essential for effector function

ABSTRACT: In response to influenza infection we found that dendritic cells (DCs), cells that are critical in mounting an effective immune response, undergo a profound metabolic shift. DCs alter the concentration and location of hundreds of proteins, including c-MYC, mediating a shift to a highly glycolytic phenotype that is also flexible in terms of fueling respiration.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lymph Node

SUBMITTER: Matthew Monroe

LAB HEAD: Heather Smallwood

PROVIDER: PXD013690 | Pride | 2021-09-08

REPOSITORIES: Pride

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Dynamic metabolic reprogramming in dendritic cells: An early response to influenza infection that is essential for effector function.

Rezinciuc Svetlana S Bezavada Lavanya L Bahadoran Azadeh A Duan Susu S Wang Ruoning R Lopez-Ferrer Daniel D Finkelstein David D McGargill Maureen A MA Green Douglas R DR Pasa-Tolic Ljiljana L Smallwood Heather S HS

PLoS pathogens 20201026 10

Infection with the influenza virus triggers an innate immune response that initiates the adaptive response to halt viral replication and spread. However, the metabolic response fueling the molecular mechanisms underlying changes in innate immune cell homeostasis remain undefined. Although influenza increases parasitized cell metabolism, it does not productively replicate in dendritic cells. To dissect these mechanisms, we compared the metabolism of dendritic cells to that of those infected with ...[more]

PMID: 33104753

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