Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Adrenal Medulla Chromaffin Cell, Adrenal Medulla
DISEASE(S): Adrenal Gland Pheochromocytoma
SUBMITTER: Kristina Bennet Emdal
LAB HEAD: Jesper Velgaard Olsen
PROVIDER: PXD001478 | Pride | 2015-05-06
REPOSITORIES: Pride
Emdal Kristina B KB Pedersen Anna-Kathrine AK Bekker-Jensen Dorte B DB Tsafou Kalliopi P KP Horn Heiko H Lindner Sven S Schulte Johannes H JH Eggert Angelika A Jensen Lars J LJ Francavilla Chiara C Olsen Jesper V JV
Science signaling 20150428 374
SH-SY5Y neuroblastoma cells respond to nerve growth factor (NGF)-mediated activation of the tropomyosin-related kinase A (TrkA) with neurite outgrowth, thereby providing a model to study neuronal differentiation. We performed a time-resolved analysis of NGF-TrkA signaling in neuroblastoma cells using mass spectrometry-based quantitative proteomics. The combination of interactome, phosphoproteome, and proteome data provided temporal insights into the molecular events downstream of NGF binding to ...[more]