Proteomics

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Elevated gpNMB in type 1 Gaucher disease patients


ABSTRACT: Gaucher disease (GD) is characterized by the presence of glucosylceramide-laden macrophages (Gaucher cells) as the result of deficiency in the lysosomal hydrolase glucocerebrosidase (GBA). Non-neuronopathic type 1 GD is effectively treated by infusions with macrophage-targeted recombinant glucocerebrosidase. We here report how LC-MSE analysis of the proteome of laser-dissected splenic Gaucher cells revealed high expression of several proteins amongst which was gpNMB. This was confirmed by histochemistry and RNA quantification. Macrophages produce gpNMB as membrane protein but release soluble fragments. In plasma of symptomatic Gaucher patients (n=59) soluble gpNMB was next found to be on average 25-fold increased prior to treatment, without overlap with control values, (control mean: 20 ng/ml; range 11-34 ng/ml vs. GD mean: 495 ng/ml; range: 137-1283 ng/ml).

INSTRUMENT(S): Synapt MS

ORGANISM(S): Fusarium oxysporum Fo47   Leishmania braziliensis MHOM/BR/75/M2904   Homo sapiens/Mus musculus xenograft   Picea abies   Dioscorea alata   Gallus   Giardia lamblia ATCC 50803   Lithobius forficatus   Macaca mulatta   Taeniopygia guttata   Bacillus pseudomycoides DSM 12442   uncultured marine microorganism   Mentha spicata   Murine leukemia virus   Buchnera aphidicola (Acyrthosiphon pisum)   Ovis   Neospora caninum   Populus tremula x Populus alba   Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150   Aedes aegypti aegypti   Leishmania donovani   Shewanella baltica   Bemisia tabaci   Olavius algarvensis spirochete endosymbiont   Trichoderma harzianum CBS 226.95   Vigna mungo   Thalassiosira pseudonana CCMP1335   Dictyostelium discoideum   Bradyrhizobium diazoefficiens USDA 110   Phaseolus vulgaris   Tropilaelaps mercedesae   Phytophthora sojae   Phytophthora capsici   Larimichthys crocea   Blumeria hordei DH14   Actinomycetia   Burkholderia pseudomallei 1026b   Thermothelomyces thermophilus ATCC 42464   Nicotiana tabacum   Aspergillus niger NRRL3   Fragaria x ananassa   Rhizobium sp. Leaf68   Haptophyta   Synechocystis sp. PCC 6803   Desulfovibrio sp. G11   Tursiops truncatus   Myzus persicae   Clostridium tetani E88   Tequatrovirus T4   Francisella orientalis FNO12   Listeria monocytogenes EGD   Leishmania major strain Friedlin   Aspergillus niger CBS 513.88   Bacteria   Haemophilus haemolyticus   Paracoccidioides brasiliensis Pb18   Burkholderia sp. 2332   Canis lupus familiaris   Yarrowia lipolytica   Burkholderia cenocepacia K56-2Valvano   Cladocopium goreaui   Nostoc sp. PCC 7120 = FACHB-418   Lineus longissimus   Galloanserae   environmental samples   Mus musculus musculus x Mus musculus castaneus   Staphylococcus sp. 1   Apostichopus japonicus   Ophrys sphegodes   Pogona vitticeps   Calicophoron daubneyi   Salmonella enterica subsp. enterica serovar Typhimurium str. 5579   Formosa sp. Hel3_A1_48   Herpes simplex virus unknown type   Butyrivibrio fibrisolvens   Ophiophagus hannah   Avicennia officinalis   Synechocystis sp. PCC 6803 substr. Kazusa   Brucella   Mycoplasma gallisepticum   Hebomoia glaucippe   Bothrops cotiara   Klebsiella variicola At-22   Lacticaseibacillus rhamnosus GG   Thermochaetoides thermophila   Oryza australiensis   Phaeodactylum tricornutum   environmental samples   Oryza sativa Indica Group   Mucilaginibacter   Olea europaea   Human alphaherpesvirus 1 strain KOS   Oncorhynchus tshawytscha   Giardia intestinalis assemblage A   Fasciola hepatica   Candida albicans SC5314   Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10   Bacillus cereus ATCC 10987   Meyerozyma guilliermondii   Plasmodium knowlesi strain H   Saccharum hybrid cultivar   Beauveria bassiana ARSEF 2860   Roseobacter denitrificans OCh 114   Trichoderma reesei QM9414   Homo   Klebsiella pneumoniae BIDMC 40   Tuber magnatum   Quercus petraea   Gammarus fossarum   Heloderma suspectum suspectum   Mollivirus sibericum   Panopea generosa   Caldanaerobacter subterraneus subsp. tengcongensis MB4   Staphylococcus aureus subsp. aureus USA300   Sanghuangporus   Spondylus gaederopus   Boehmeria nivea   Schmidtea mediterranea   Streptomyces coelicolor A3(2)   Chlorella vulgaris   Mycobacterium marinum ATCC BAA-535   Bacillus cereus ATCC 14579   Russula atropurpurea   Bodo saltans   Bienertia sinuspersici   Liquorilactobacillus hordei   Perkinsus marinus   Fusarium graminearum GZ3639   Apis mellifera   Pseudomonas stutzeri   Brassica oleracea var. botrytis   Human herpesvirus 4 type 1   Sulfolobus acidocaldarius   Corynebacterium glutamicum ATCC 13032   Lens culinaris   Thermococcus gammatolerans EJ3   Komagataella phaffii   Volvariella volvacea V23   Ruminiclostridium papyrosolvens DSM 2782   Syntrophomonas wolfei   Methylocystis sp. SC2   Vitis riparia   Pisolithus tinctorius Marx 270   Saccharum sp.   Tannerella forsythia   Fusarium oxysporum f. sp. cucumerinum   Pomacea canaliculata   Dactylorhiza   Cervus elaphus elaphus   albimanus section   Salmonella enterica subsp. enterica serovar Typhimurium str. SDT1291   Leishmania mexicana MHOM/GT/2001/U1103   Bovine leukemia virus   Streptococcus equi subsp. equi 4047   Rhizorhabdus wittichii   Steinernema carpocapsae   Streptococcus pneumoniae TIGR4   Olavius algarvensis Gamma 3 endosymbiont   Meleagris gallopavo   gut metagenome   Ascaris suum   uncultured Phormidium sp.   Solanum lycopersicum   Streptococcus agalactiae FSL S3-026   Frankia alni ACN14a   Staphylococcus haemolyticus   Latilactobacillus curvatus   Bartonella quintana JK 31   Streptomyces avidinii   H1N1 subtype   Tetrahymena thermophila   Trypanosoma brucei   Schizosaccharomyces pombe 927   Planococcus halocryophilus Or1   Schizosaccharomyces pombe   Cervus nippon nippon   Cupiennius salei   Ictalurus punctatus   Synechococcus elongatus PCC 7942 = FACHB-805   Schistosoma haematobium   Tradescantia spathacea   Gadus morhua   Strongyloides venezuelensis   Aspergillus fumigatus   Salmonella enterica subsp. enterica serovar Typhi str. CT18   Komagataella pastoris   Pseudomonas putida KT2440   Halobacterium salinarum R1   Botrytis cinerea   Olavius algarvensis Delta 1 endosymbiont   Crassostrea gigas   Bombyx mori   Arvicola   Bos taurus   Burkholderia ubonensis MSMB22   Oryzias latipes   Struthio camelus   Saccostrea glomerata   Clostridioides difficile R20291   Epstein-barr virus strain p3hr-1   Lactococcus lactis subsp. lactis Il1403   Scolopendra morsitans   Latrodectus hesperus   Cecropia peltata   Lymnaea stagnalis   Francisella tularensis subsp. holarctica FSC200   Pseudomonas putida F1   Arabidopsis thaliana   Sedum plumbizincicola   Toxoplasma gondii ME49   Haemaphysalis longicornis   Mycoplasma pneumoniae M129-B7   Oreochromis niloticus niloticus   Picea likiangensis var. rubescens   Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821   Haemonchus contortus   Brucella abortus   Pseudomonas fluorescens SBW25   Sarcoptes scabiei   Mycobacterium avium subsp. paratuberculosis K-10   Sus scrofa   Enterobacter cloacae   Klebsiella pneumoniae JH1   Glia   Roseburia   Botrytis cinerea B05.10   Gallus gallus   rat gut metagenome   Bothrops leucurus   Drosophila   Synechococcus cyanophage syn   Mycobacterium tuberculosis SP10   Geobacter sulfurreducens   Luteibacter   Francisella tularensis subsp. novicida U112   Toxoplasma gondii type III   Mycobacterium tuberculosis H37Rv   Pyrococcus furiosus   Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499   Yersinia pseudotuberculosis   Pyrococcus abyssi   Human alphaherpesvirus 1   Bacillus mycoides DSM 2048   Tetronarce californica   Coxsackievirus B3   Parasynechococcus marenigrum WH 8102   Shigella dysenteriae   Bothrops jararacussu   Hominidae   [Ruminococcus] gnavus   Cryptochiton stelleri   Platichthys flesus   Dirofilaria immitis   Trichomonas gallinae   Trypanosoma cruzi strain CL Brener   Paracoccus denitrificans PD1222   Ianthella basta   Campylobacter concisus UNSWCD   Aspergillus nidulans TN02A3   soil bacterium TS1114R   Thalassiosira cf. oceanica   Clostridium autoethanogenum   Ricinus communis   Burkholderia thailandensis   Pseudoalteromonas sp. D41   Priestia megaterium DSM 319   Lysiphlebus fabarum   Lactobacillus   Eulimnogammarus cyaneus   Phytophthora capsici LT1534   Schizosaccharomyces pombe OY26   Ovis aries   Nephila clavipes   Petunia   Bacillus amyloliquefaciens   Bombus terrestris audax   Plasmodium berghei ANKA   Ficus carica   Thermus thermophilus HB8   Cyclopes didactylus   Salmonella enterica subsp. enterica serovar Typhimurium str. D23580   Eremothecium gossypii   Triticum aestivum   Ustilaginoidea virens   Aspergillus niger   Borreliella burgdorferi B31   Cloning vector pEGFP-C1   Tuber indicum   freshwater sediment metagenome   Staphylococcus epidermidis   Citrus maxima   Ceuthophilus sp. Ceu_104_TX_San_Rattlesnake   environmental samples   Clostridium saccharoperbutylacetonicum   Aves   Saccharopolyspora erythraea   Pseudomonas aeruginosa PAO1   Harmonia axyridis   Trypanosoma brucei brucei TREU927   Lachancea kluyveri   human metagenome   Mengo virus   Human herpesvirus 2 strain 186   Ostreococcus tauri   Entamoeba histolytica   Cynodon dactylon   Campylobacter fetus subsp. fetus 82-40   Sphingomonas sp. Leaf257   Anopheles stephensi   Globicatella sanguinis   Bungarus   Coffea arabica   Histomonas meleagridis   Avena strigosa   Haloferax volcanii   Escherichia coli K-12   Piaractus mesopotamicus   Vibrio parahaemolyticus   Aedes aegypti densovirus   Ophrys x arachnitiformis subsp. archipelagi   Olavius algarvensis   Shigella sonnei 53G   Populus tremula x Populus tremuloides   Anopheles culicifacies B   Callinectes sapidus   Marchantia polymorpha subsp. ruderalis   Mycoplasma pneumoniae M129   Siphoviridae   Megoura viciae   Mytilus sp. CHGF4   Acidithiobacillus ferrooxidans ATCC 53993   Escherichia coli str. K-12 substr. MG1655   Spirochaeta sp. ELBA   Paramecium tetraurelia   Clostridium phage c-st   Penaeus vannamei   Bacillus subtilis subsp. subtilis str. 168   Apteronotus leptorhynchus   Shewanella oneidensis MR-1   Pan troglodytes   Melioribacter roseus P3M-2   Nicotiana benthamiana   Coccinia grandis   Candida parapsilosis CDC317   Plasmodium yoelii yoelii   Halobacterium   Chromatiales bacterium OalgGamma1   Candidatus Protochlamydia amoebophila UWE25   Marthasterias glacialis   Craterostigma plantagineum   Theobroma cacao   Amphora coffeiformis   Morchella importuna   Nephotettix cincticeps   Lilium   Kluyveromyces lactis NRRL Y-1140   Capsicum annuum var. annuum   Francisella tularensis subsp. holarctica   Streptococcus equi subsp. equi   Cryptococcus neoformans var. grubii H99W   Podospora anserina S mat+   Trypanosoma cruzi   Anopheles gambiae str. PEST   Hepatitis E virus type 1   Rhizobium cf. leguminosarum   Toxoplasma gondii GT1   Burkholderia cenocepacia   Pseudomonas putida BIRD-1   Pseudomonas aeruginosa PAO1H2O   Breviolum minutum   Streptococcus agalactiae   Pseudotsuga menziesii var. menziesii   Mycoplasma gallisepticum S6   Saccharomyces cerevisiae   Coffea eugenioides   Parasteatoda tepidariorum   Saccharomyces cerevisiae EC1118   Vitis vinifera   Photobacterium profundum SS9   Rhodopseudomonas palustris   Caenorhabditis elegans   Vipera berus berus   Cenchrus americanus   wastewater metagenome   Alternaria tomato   Mus musculus   Parhyale hawaiensis   Cervus nippon hortulorum   Oryctolagus cuniculus   Candidatus Nitrospira inopinata   Strigomonas culicis   Bartonella quintana   Echinococcus granulosus   Quercus robur   (Vitis vinifera x Vitis berlandieri) x Vitis berlandieri   Cyprinus carpio   Malus domestica   Eukaryota   Bursaphelenchus xylophilus   Deinococcus radiodurans R1   Andreprevotia sp. IGB-42   mixed culture metagenome   Heliocidaris erythrogramma   Salmonella enterica subsp. enterica serovar Typhimurium str. A130   Escherichia coli O157:H7 str. EDL933   Ornithodoros moubata   Mycobacterium tuberculosis SP7   Flavobacterium sp. 316   Porphyromonas gingivalis W83   Brucella abortus S19   Vicia faba   Synechococcus phage S-SSM7   Strawberry leafy fruit phytoplasma   Staphylococcus aureus subsp. aureus MRSA252   Orycteropus afer   Candidatus Kuenenia stuttgartiensis   Coxiella burnetii RSA 493   Emiliania   Naja ashei   Cleome angustifolia   Euzebya tangerina   Craterostigmus tasmanianus   Passiflora edulis   Kluyveromyces marxianus   Drosophila melanogaster   unclassified Candidatus Omnitrophica   Paramoeba perurans   Medicago truncatula var. truncatula   Nerodia clarkii   Haloferax volcanii DS2   Equus caballus   Cytomegalovirus   Rhodopseudomonas palustris CGA009   Crustacea   Mustela putorius furo   Acyrthosiphon pisum   Bubalus bubalis   Rattus rattus   Phaeobacter sp. MED193   Medicago sativa   Human immunodeficiency virus   Escherichia coli O157:H7 str. TW14359   Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044   Oryza sativa Japonica Group   Streptococcus dysgalactiae subsp. equisimilis SK1249   Aspergillus flavus   Leishmania mexicana   anaerobic digester metagenome   Penicillium sp. B12   Pinus pinaster   Riptortus pedestris   Halobacterium salinarum   Schizosaccharomyces pombe 972h-   Candidatus Pelagibacter ubique   Physcomitrella   Spiroplasma melliferum   Brugia malayi   Strigamia maritima   Clostridium butyricum E4 str. BoNT E BL5262   Sorghum bicolor   Clostridium perfringens   Pseudomonas pseudoalcaligenes CECT 5344   Bothrops brazili   Sciuridae   Bicyclus anynana   Scutigera coleoptrata   Taenia hydatigena   Clostridioides difficile ATCC 43255   Acinetobacter baumannii   Betaproteobacteria bacterium RIFCSPLOWO2_02_64_14   Pseudomonas syringae   Ctenopharyngodon idella   Toxoplasma gondii CtCo5   Scheffersomyces stipitis   Mesocricetus auratus   Homo sapiens   Filifactor alocis   Chlorocebus sabaeus   Heterorhabditis megidis   Arachis hypogaea   Mycolicibacterium smegmatis MC2 155   Tuber melanosporum Mel28   Phascolarctos cinereus   Solanum tuberosum   Shigella flexneri 2a str. 2457T   Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841   Clostridioides difficile 630   Roseobacter sp. MED193   Armoracia rusticana   Natronomonas pharaonis DSM 2160   Chaetoceros sp.   Dictyostelium discoideum AX4   Roseburia intestinalis L1-82   Potentilla saundersiana   Olavius algarvensis sulfate-reducing endosymbiont   Brachyspiraceae   Saccharina japonica   Mycoplasmopsis agalactiae   Staphylococcus aureus subsp. aureus NCTC 8325   Neisseria meningitidis MC58   Euprymna scolopes   Pseudomonas aeruginosa PA14   Pongo pygmaeus   Rheum palmatum   Octopodiformes   Ustilago maydis   Simulium damnosum s.l. Me1   Aeromonas salmonicida subsp. salmonicida   Plasmodium falciparum   Aspergillus nidulans   environmental samples   Aggregatibacter actinomycetemcomitans D7S-1   Francisella tularensis   Mycobacterium tuberculosis M24   Equus asinus   Fraxinus nigra   Vibrio anguillarum   Bradyrhizobium japonicum   Catenibacterium   Apis mellifera ligustica   Ictalurid herpesvirus 1   Escherichia coli Nissle 1917   Streptomyces coelicolor   Trichechus manatus   Microcystis aeruginosa   Legionella pneumophila subsp. pneumophila str. Philadelphia 1   Dendroaspis polylepis polylepis   Bothrops insularis   Candida albicans   Felis catus   unclassified Marseilleviridae   Lobaria pulmonaria   Cicer arietinum   Brucella melitensis   Salmonella enterica subsp. enterica serovar Enteritidis str. P125109   Haemophilus influenzae   Quercus suber   Streptococcus pneumoniae D39   Riftia pachyptila   Mylodon darwinii   Passer domesticus domesticus   Zea mays   Zymomonas mobilis   Thermochaetoides thermophila DSM 1495   metagenomes   Escherichia coli BL21(DE3)   Dialister   Leishmania infantum JPCM5   Pedobacter sp.   Corynebacterium diphtheriae bv. mitis str. ISS 3319   Corynebacterium diphtheriae NCTC 13129   Phytophthora infestans   Synechocystis sp.   Pectobacterium carotovorum   Mycobacteroides abscessus   Bothrops jararaca   Strongylocentrotus purpuratus   Leishmania major   uncultured bacterium   Schizosaccharomyces pombe DM3650   Schistosoma mansoni   Candidatus Accumulibacter phosphatis   Nelumbo nucifera   Capsaspora owczarzaki   Bothrops moojeni   Selaginella moellendorffii   Peniophora incarnata   Pseudomonas aeruginosa   Stephanorhinus   Trichoderma sp. 1 YW-2011   Dioscorea oppositifolia   Francisella tularensis subsp. holarctica LVS   Campylobacter concisus 13826   Bradyrhizobium   Bacillus thuringiensis   Catalpa fargesii   Staphylococcus cohnii   Clavibacter michiganensis subsp. nebraskensis NCPPB 2581   Candidatus Thioglobus autotrophicus   Deinococcus deserti VCD115   Mycobacterium tuberculosis TKK-01-0032   Acholeplasma laidlawii PG-8A   Trichoderma reesei RUT C-30   Chenopodium quinoa   Hordeum vulgare   Flavobacterium columnare   Giardia intestinalis   Acinetobacter sp. PM-14   Chlamydomonas reinhardtii   Spirometra erinaceieuropaei   Human herpesvirus 5 strain AD169   Oryza sativa   Gorilla gorilla   Chlorella sp. SAG 211-18   Lactococcus lactis subsp. cremoris UC509.9   Escherichia coli   Capsicum annuum   Citrus sinensis   Paenibacillus sp.   Vibrio natriegens NBRC 15636 = ATCC 14048 = DSM 759   Toxoplasma gondii   Aspergillus aff. niger A2   Apis mellifera pomonella   Bacillus thuringiensis serovar berliner ATCC 10792   Fusarium oxysporum f. sp. lycopersici 4287   Lactococcus lactis subsp. cremoris MG1363   Vibrio cholerae O1 biovar El Tor str. N16961   Alteromonadales   Manica rubida   Tuber aestivum   Daphnia   Granulicatella adiacens ATCC 49175   Merluccius bilinearis   Acanthamoeba castellanii   Coxiella burnetii   Bison   Ixodes ricinus   Nostoc punctiforme PCC 73102   Pseudomonas aeruginosa LESB58   Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S   Acanthoscurria geniculata   Anas platyrhynchos   Cryptococcus neoformans var. grubii H99S   Cavia porcellus   Streptococcus pyogenes M1 GAS   Pogonomyrmex rugosus   Scophthalmus maximus   Aspergillus nidulans FGSC A4   Coffea canephora   Candidatus Accumulibacter   Entamoeba histolytica HM-1:IMSS-A   prokaryotic environmental samples   Agaricus bisporus   Faustovirus   Amaranthus tricolor   Staphylococcus aureus subsp. aureus USA300_TCH1516   Candida tropicalis   Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344   [Candida] glabrata   Agrobacterium tumefaciens   Lactococcus phage   Olavius algarvensis Gamma 1 endosymbiont   Desulfovibrio ferrophilus   Pinus radiata   Danio rerio   Olavius algarvensis Delta 4 endosymbiont   Acinetobacter baumannii ACICU   Oscillatoriaceae cyanobacterium   Norovirus   Granulicella sp.   Magnaporthe sp. MG05   Nematostella vectensis   Mytilus galloprovincialis   Bordetella pertussis Tohama I   Salmo sp.   Pseudotsuga menziesii   Candidatus Methylomirabilis oxyfera   Archaea   Equus sp.   Muvirus mu   Escherichia coli O157:NM   Wolbachia sp. wMelPop   Brassica oleracea var. italica   Moraxella catarrhalis   Crassostrea hongkongensis   Macaca fascicularis   Gossypium hirsutum   Ectocarpus siliculosus   Gammarus roeselii   Mycobacterium tuberculosis SP1   Lactobacillus johnsonii N6.2   Angiostrongylus cantonensis   Enchytraeus crypticus   Enterococcus faecalis   Aeropyrum pernix K1   Emiliania huxleyi   Pyrus x bretschneideri   Neptuniibacter caesariensis   Oryctolagus sp. 'Rabbit_OD'   Lagomorpha   Cyanophora paradoxa   Delonix regia   Desulforamulus reducens MI-1   Rhizophagus irregularis   Pachysolen tannophilus NRRL Y-2460   Marseillevirus   Sus scrofa domesticus   Acinetobacter baumannii D1279779   Ganoderma lingzhi   Durusdinium trenchii   Listeria monocytogenes EGD-e   Amphibalanus amphitrite   Viridiplantae   Mariprofundus ferrooxydans   Mycolicibacterium smegmatis   Pyricularia oryzae   Ceratopteris richardii   Butyrivibrio proteoclasticus B316   Rattus norvegicus   Vitis   Carica papaya   Anopheles culicifacies A   Xanthomonas oryzae pv. oryzae PXO99A   unidentified   Chlamydia trachomatis D/UW-3/CX   Sulfolobus islandicus REY15A   Noccaea caerulescens   Bradyrhizobium diazoefficiens   Faecalibacterium prausnitzii   Liquorilactobacillus nagelii   Nilaparvata lugens   Mycobacterium tuberculosis   Malassezia sympodialis ATCC 42132   Brassica napus   Stylosanthes guianensis   Bothrops neuwiedi   Onchocerca ochengi   Deltaproteobacteria bacterium RIFCSPLOWO2_12_FULL_50_11   Homo sapiens subsp. 'Denisova'   Mayaro virus (strain Brazil)   Medicago truncatula   Oryctolagus cuniculus cuniculus   Vespula vulgaris   Python molurus   Streptococcus pneumoniae SP14-BS69   Austrolebias   Rhodococcus jostii RHA1   Exiguobacterium sp. SH31   Hendra virus horse/Australia/Hendra/1994   Trypanosoma   Staphylococcus aureus   Campylobacter jejuni   Bacillus toyonensis BCT-7112   Synechococcus phage syn9   environmental samples   Ciona intestinalis   Aggregatibacter actinomycetemcomitans   Beta vulgaris subsp. vulgaris   Aspergillus fumigatus Af293   hybrid   Human alphaherpesvirus 1 strain 17   Camelus dromedarius   Quercus ilex   Tarenaya hassleriana   Passer hispaniolensis   Streptococcus pneumoniae   Human immunodeficiency virus 1   Neurospora crassa   Aspergillus flavus NRRL3357   Tuber albidum   Saccharomyces mikatae IFO 1815   Heterosigma akashiwo   Cryptococcus neoformans var. grubii H99   Taenia solium   Toxoplasma gondii RH   Neospora caninum Liverpool   Oryctolagus cuniculus algirus   Tetrahymena thermophila SB210   Eriocheir sinensis   Dasypogon diadema   Trypanosoma cruzi strain Esmeraldo   Hyalella azteca   Camellia sinensis   Helicobacter pylori 26695   Ophrys garganica   Coronavirus PREDICT CoV-2   Schizophyllum commune H4-8   Cricetulus griseus   Coprococcus eutactus   Moringa oleifera   Daphnia magna   Populus trichocarpa   Asterias rubens   Trichinella britovi   Brachypodium distachyon   Elaeis guineensis   Eubacterium limosum   Trichoderma reesei QM6a   Mycobacterium tuberculosis KZN 1435   Clostridioides difficile 050-P50-2011   Labeo rohita   Mycobacterium tuberculosis SP22   Phytophthora pisi   Naja sagittifera   Xenopus laevis   Pisum sativum   Clostridioides difficile   Thermoplasma acidophilum DSM 1728   Pyricularia oryzae B157   Thermococcus gammatolerans   Serendipita indica   Streptococcus pyogenes ABC020006030   Channa striata   Citrobacter rodentium   Streptococcus pneumoniae R6   Sorangium cellulosum So ce56   Ursus arctos arctos   Mycobacterium tuberculosis H37Rv_2009   Yersinia pestis   Mytilus edulis/galloprovincialis MCLGV-2007   Pseudomonas aeruginosa LESlike1   Leishmania donovani Ld 2001   Palaemonetes sp. common grass shrimp associated circular virus   Oreochromis mossambicus   Pseudomonas fluorescens   Klebsiella pneumoniae   Capra hircus   Tapirus terrestris   Sphingobium chlorophenolicum   Helicobacter pylori J99   Gynandropsis gynandra   Arabidopsis   Salmo salar   Oncorhynchus mykiss   Gnathostoma spinigerum   Bacillus mycoides NBRC 101238 = DSM 11821   Daktulosphaira vitifoliae   Neisseria gonorrhoeae FA 1090   Trifolium pratense subsp. pratense   Myxococcus xanthus DK 1622   Streptococcus pyogenes STAB901   Sinorhizobium meliloti BL225C   Stenotrophomonas maltophilia   Physcomitrium patens   Sophora alopecuroides   Colinus virginianus   Microbiota   Saccharomyces cerevisiae W303   Staphylococcus pseudintermedius   Dendroaspis angusticeps   Rhodotorula toruloides   Drosophila pseudoobscura   Lotus japonicus   Thermosynechococcus vestitus BP-1   Synechocystis sp. PCC 6803 substr. GT-I   Rhipicephalus microplus   Loxodonta africana   Dinoroseobacter shibae DFL 12 = DSM 16493   Teleogryllus oceanicus   Hydra vulgaris   Citrullus lanatus   Musa acuminata subsp. acuminata   Acanthoscurria gomesiana   Listeria phage A118   Puccinellia tenuiflora   Hippopotamus amphibius   Bacillus subtilis   Spiroplasma melliferum KC3   Mytilus edulis   Chlamydia trachomatis 434/Bu   Oenococcus oeni   Naja mandalayensis   Panicum virgatum   Enterococcus mundtii CRL35   Burkholderia cenocepacia H111   Cairina moschata   Severe acute respiratory syndrome coronavirus 2   Chlorocebus aethiops   Populus yunnanensis   Plasmodium falciparum 3D7   Novosphingobium nitrogenifigens   Staphylococcus aureus subsp. aureus USA300_FPR3757   Rhodospirillum rubrum ATCC 11170   Daphnia pulex   Fusarium sp.   Cupriavidus metallidurans   Lachancea waltii NCYC 2644   sediment metagenome   Bacillus cytotoxicus NVH 391-98   Ensifer adhaerens   Helianthus annuus   Thymallus thymallus   Piper nigrum   Candidatus Endoriftia persephone   Allexis   Acinetobacter baumannii AB307-0294   Cercopithecidae   rhizosphere soil bacteria ensemble   Lingula anatina   Gammarus pulex   Listeria monocytogenes   Ruminiclostridium cellulolyticum H10   Acipenser transmontanus   Brachylophosaurus canadensis   biofilm metagenome   Crotalus durissus terrificus   Onchocerca volvulus   Renibacterium salmoninarum ATCC 33209   Paucilactobacillus suebicus   Lentinus crinitus   Trypanosoma brucei brucei   Pseudoliparis swirei   Mycobacterium tuberculosis SP13   Influenza A virus (H1N1)   Dokdonia sp. MED134   Yersinia enterocolitica   Sarcophilus harrisii   Pteropus alecto   Bacteroides caccae   Escherichia coli O157:H7   Synechococcus elongatus   Streptococcus thermophilus LMD-9   Sparus aurata   Fraxinus mandshurica   Fagus grandifolia   Methanosarcina acetivorans   Aerococcus urinae NBRC 15544 = CCUG 36881   Aspergillus terreus NIH2624   Brassica oleracea var. gemmifera   Naja naja   Conus geographus   Aspergillus giganteus   Dentex dentex   Zygaena filipendulae   Crithidia fasciculata   Mammuthus sp.   Cyclotella cryptica   Vibrio alginolyticus   Viruses   Pyricularia oryzae P131   Plasmodium sp. pBT9   Glycine max   Canis lupus x Canis lupus familiaris   Piscirickettsia salmonis AUSTRAL-005   Gorilla   Ictidomys tridecemlineatus   Streptococcus pyogenes   Beta vulgaris  

TISSUE(S): Spleen, Macrophage

DISEASE(S): Gaucher's Disease

SUBMITTER: Gertjan Kramer  

LAB HEAD: J.M.F.G. Aerts

PROVIDER: PXD001598 | Pride | 2016-09-27

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
121108_D2_028.raw.zip Raw
121108_D2_028_20141210154822.zip Other
121108_D2_029.raw.zip Raw
121108_D2_029_20141210160200.zip Other
121108_D2_030.raw.zip Raw
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Publications


Gaucher disease is caused by inherited deficiency of lysosomal glucocerebrosidase. Proteome analysis of laser-dissected splenic Gaucher cells revealed increased amounts of glycoprotein nonmetastatic melanoma protein B (gpNMB). Plasma gpNMB was also elevated, correlating with chitotriosidase and CCL18, which are established markers for human Gaucher cells. In Gaucher mice, gpNMB is also produced by Gaucher cells. Correction of glucocerebrosidase deficiency in mice by gene transfer or pharmacologi  ...[more]

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