Proteomics

Dataset Information

0

Effects of daf-2 mutation, dietary restriction and age on C.elegans proteome


ABSTRACT: The overarching project goal was to describe proteome differences between long- and normal-living C.elegans worms. The associated publications are http://www.ncbi.nlm.nih.gov/pubmed/24555535 http://www.ncbi.nlm.nih.gov/pubmed/24002365

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Caenorhabditis Elegans

TISSUE(S): Whole Body

SUBMITTER: Vlad Petyuk  

LAB HEAD: Vladislav Petyuk

PROVIDER: PXD002161 | Pride | 2015-05-13

REPOSITORIES: Pride

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Publications

Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans.

Depuydt Geert G   Xie Fang F   Petyuk Vladislav A VA   Shanmugam Nilesh N   Smolders Arne A   Dhondt Ineke I   Brewer Heather M HM   Camp David G DG   Smith Richard D RD   Braeckman Bart P BP  

Molecular & cellular proteomics : MCP 20130903 12


Reduced signaling through the C. elegans insulin/insulin-like growth factor-1-like tyrosine kinase receptor daf-2 and dietary restriction via bacterial dilution are two well-characterized lifespan-extending interventions that operate in parallel or through (partially) independent mechanisms. Using accurate mass and time tag LC-MS/MS quantitative proteomics, we detected that the abundance of a large number of ribosomal subunits is decreased in response to dietary restriction, as well as in the da  ...[more]

Publication: 1/2

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