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Global profiling of the C.elegans redoxome

ABSTRACT: We used several state-of-the-art site-centric chemoproteomics to systematically map three distinct types of redox forms (-SH, -SOH, and -SO2H) in C.elegans and quantify their dynamic changes in response to a short-term oxidative stress.

INSTRUMENT(S): Q Exactive HF, Q Exactive

ORGANISM(S): Caenorhabditis Elegans

SUBMITTER: Jing Yang

LAB HEAD: Jing Yang

PROVIDER: PXD018575 | Pride | 2021-01-28

REPOSITORIES: Pride

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Global profiling of distinct cysteine redox forms reveals wide-ranging redox regulation in C. elegans.

Meng Jin J Fu Ling L Liu Keke K Tian Caiping C Wu Ziyun Z Jung Youngeun Y Ferreira Renan B RB Carroll Kate S KS Blackwell T Keith TK Yang Jing J

Nature communications 20210303 1

Post-translational changes in the redox state of cysteine residues can rapidly and reversibly alter protein functions, thereby modulating biological processes. The nematode C. elegans is an ideal model organism for studying cysteine-mediated redox signaling at a network level. Here we present a comprehensive, quantitative, and site-specific profile of the intrinsic reactivity of the cysteinome in wild-type C. elegans. We also describe a global characterization of the C. elegans redoxome in which ...[more]

PMID: 33658510

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