Reproductive aging drives protein accumulation in the uterus and limits lifespan in C. elegans
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Caenorhabditis Elegans
TISSUE(S): Whole Body
SUBMITTER: 
Izumi Hinkson
LAB HEAD: Josh Elias
PROVIDER: PXD002432 | Pride | 2018-10-24
REPOSITORIES: Pride
Publications
Reproductive Aging Drives Protein Accumulation in the Uterus and Limits Lifespan in C. elegans.
Zimmerman Stephanie M SM Hinkson Izumi V IV Elias Joshua E JE Kim Stuart K SK
PLoS genetics 20151211 12
Aging in Caenorhabditis elegans is characterized by widespread physiological and molecular changes, but the mechanisms that determine the rate at which these changes occur are not well understood. In this study, we identify a novel link between reproductive aging and somatic aging in C. elegans. By measuring global age-related changes in the proteome, we identify a previously uncharacterized group of secreted proteins in the adult uterus that dramatically increase in abundance with age. This acc ...[more]
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