Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Primary Cell, Hepatocyte, Liver, Cell Culture, Keratinocyte
DISEASE(S): Hepatocellular Carcinoma
SUBMITTER: Alexander Held
LAB HEAD: Marcel Schilling
PROVIDER: PXD002460 | Pride | 2016-02-08
REPOSITORIES: Pride
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141201_04_ERK_01.mzXML | Mzxml | |||
141201_04_ERK_01.raw | Raw | |||
141201_06_ERK_02.mzXML | Mzxml | |||
141201_06_ERK_02.raw | Raw | |||
141201_08_ERK_03.mzXML | Mzxml |
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Iwamoto Nao N D'Alessandro Lorenza A LA Depner Sofia S Hahn Bettina B Kramer Bernhard A BA Lucarelli Philippe P Vlasov Artyom A Stepath Markus M Böhm Martin E ME Deharde Daniela D Damm Georg G Seehofer Daniel D Lehmann Wolf D WD Klingmüller Ursula U Schilling Marcel M
Science signaling 20160202 413
The same pathway, such as the mitogen-activated protein kinase (MAPK) pathway, can produce different cellular responses, depending on stimulus or cell type. We examined the phosphorylation dynamics of the MAPK kinase MEK and its targets extracellular signal-regulated kinase 1 and 2 (ERK1/2) in primary hepatocytes and the transformed keratinocyte cell line HaCaT A5 exposed to either hepatocyte growth factor or interleukin-6. By combining quantitative mass spectrometry with dynamic modeling, we el ...[more]