Dataset Information
Analysis of mitochondrial proteins in the surviving myocardium after ischemia identifies mitochondrial pyruvate carrier expression as possible mediator of tissue viability.
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)
TISSUE(S): Heart
DISEASE(S): Coronary Artery Disease
SUBMITTER: 
Javier Barallobre-Barreiro
LAB HEAD: Nieves Domenech Garcia
PROVIDER: PXD002989 | Pride | 2016-04-06
REPOSITORIES: Pride
Publications
Analysis of Mitochondrial Proteins in the Surviving Myocardium after Ischemia Identifies Mitochondrial Pyruvate Carrier Expression as Possible Mediator of Tissue Viability.
Molecular & cellular proteomics : MCP 20151118 1
The endogenous mechanisms contributing to tissue survival following myocardial infarction are not fully understood. We investigated the alterations in the mitochondrial proteome after ischemia-reperfusion (I/R) and its possible implications on cell survival. Mitochondrial proteomic analysis of cardiac tissue from an in vivo porcine I/R model found that surviving tissue in the peri-infarct border zone showed increased expression of several proteins. Notably, these included subunits of the mitocho ...[more]
