Proteomics

Dataset Information

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The E. coli type III secreted effectors NleB and EspL interact with the microtubule associated protein ensconsin to disrupt vesicle trafficking, part 2

ABSTRACT: This is the companion dataset to PXD002933. This contains additional RAW files

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human) Escherichia Coli

SUBMITTER: Leonard Foster  

LAB HEAD: Leonard Foster

PROVIDER: PXD002995 | Pride | 2016-12-22

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
MSQuant.xls Xls
SPR302A121MA2-40-10900.RAW Raw
SPR302A122MA2-40-11576.RAW Raw
SPR302A123MA2-40-11577.RAW Raw
SPR302A124MA2-40-11578.RAW Raw
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Publications

Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic Escherichia coli Type III Secretion System Effectors.

Law Robyn J RJ   Law Hong T HT   Scurll Joshua M JM   Scholz Roland R   Santos Andrew S AS   Shames Stephanie R SR   Deng Wanyin W   Croxen Matthew A MA   Li Yuling Y   de Hoog Carmen L CL   van der Heijden Joris J   Foster Leonard J LJ   Guttman Julian A JA   Finlay B Brett BB  

Journal of proteome research 20160328 5

Enteropathogenic and enterohemorrhagic Escherichia coli cause enteric diseases resulting in significant morbidity and mortality worldwide. These pathogens remain extracellular and translocate a set of type III secreted effector proteins into host cells to promote bacterial virulence. Effectors manipulate host cell pathways to facilitate infection by interacting with a variety of host targets, yet the binding partners and mechanism of action of many effectors remain elusive. We performed a mass s  ...[more]

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