Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: kerwin chiang
LAB HEAD: Daniel Figeys
PROVIDER: PXD003635 | Pride | 2017-04-24
REPOSITORIES: Pride
Mendoza-Viveros Lucia L Chiang Cheng-Kang CK Ong Jonathan L K JLK Hegazi Sara S Cheng Arthur H AH Bouchard-Cannon Pascale P Fana Michael M Lowden Christopher C Zhang Peng P Bothorel Béatrice B Michniewicz Matthew G MG Magill Stephen T ST Holmes Melissa M MM Goodman Richard H RH Simonneaux Valérie V Figeys Daniel D Cheng Hai-Ying M HM
Cell reports 20170401 3
The central circadian pacemaker, the suprachiasmatic nucleus (SCN), encodes day length information by mechanisms that are not well understood. Here, we report that genetic ablation of miR-132/212 alters entrainment to different day lengths and non-24 hr day-night cycles, as well as photoperiodic regulation of Period2 expression in the SCN. SCN neurons from miR-132/212-deficient mice have significantly reduced dendritic spine density, along with altered methyl CpG-binding protein (MeCP2) rhythms. ...[more]