Dataset Information

Identification of quantitative proteomic differences between mycobacterial lineages with altered virulence

ABSTRACT: Mycobacterium tuberculosis is the causitive agent of TB, which is a global epidemic that has claimed millions of lives. Some clinical strains of M.tb have significantly more severe clinical outcomes, while some other mycobacteria ordinarily do not cause disease in humans. The biological processes underpinning this difference are poorly understood. Thus, this project aimed to identify proteomic differences between more virulent strains of the MTBC (Beijing, J37Rv, CAS and LAM) vs those strains that only cause disease in severely immune compromised humans (Bovis, Smegmatis and Avium). We hypothesise that these differences may offer insight into the molecular mechanisms by which M.tb has become more virulent by evading drug treatment or evading the host immune system more effectively.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mycobacterium Tuberculosis Cas Mycobacterium Bovis Bcg Mycobacterium Tuberculosis Lam7 Mycobacterium Avium 100 Mycobacterium Bovis Str. Ravenel Mycobacterium Tuberculosis Str. Beijing/w Bt1 Mycobacterium Tuberculosis H37rv

TISSUE(S): Cell Culture

SUBMITTER: Bridget Calder

LAB HEAD: Jonathan Blackburn

PROVIDER: PXD004165 | Pride | 2016-05-23

REPOSITORIES: Pride

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Publications

Identification of Quantitative Proteomic Differences between Mycobacterium tuberculosis Lineages with Altered Virulence.

Peters Julian S JS Calder Bridget B Gonnelli Giulia G Degroeve Sven S Rajaonarifara Elinambinina E Mulder Nicola N Soares Nelson C NC Martens Lennart L Blackburn Jonathan M JM

Frontiers in microbiology 20160531

Evidence currently suggests that as a species Mycobacterium tuberculosis exhibits very little genomic sequence diversity. Despite limited genetic variability, members of the M. tuberculosis complex (MTBC) have been shown to exhibit vast discrepancies in phenotypic presentation in terms of virulence, elicited immune response and transmissibility. Here, we used qualitative and quantitative mass spectrometry tools to investigate the proteomes of seven clinically-relevant mycobacterial strains-four ...[more]

PMID: 27303394

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Dataset Information

Identification of quantitative proteomic differences between mycobacterial lineages with altered virulence

Publications

Identification of Quantitative Proteomic Differences between Mycobacterium tuberculosis Lineages with Altered Virulence.

Similar Datasets

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