Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
DISEASE(S): Disease Free
SUBMITTER: Alex von kriegsheim
LAB HEAD: alex von kriegsheim
PROVIDER: PXD004334 | Pride | 2018-07-11
REPOSITORIES: Pride
Yeyati Patricia L PL Schiller Rachel R Mali Girish G Kasioulis Ioannis I Kawamura Akane A Adams Ian R IR Playfoot Christopher C Gilbert Nick N van Heyningen Veronica V Wills Jimi J von Kriegsheim Alex A Finch Andrew A Sakai Juro J Schofield Christopher J CJ Jackson Ian J IJ Mill Pleasantine P
The Journal of cell biology 20170228 4
Cilia assembly and disassembly are coupled to actin dynamics, ensuring a coherent cellular response during environmental change. How these processes are integrated remains undefined. The histone lysine demethylase KDM3A plays important roles in organismal homeostasis. Loss-of-function mouse models of <i>Kdm3a</i> phenocopy features associated with human ciliopathies, whereas human somatic mutations correlate with poor cancer prognosis. We demonstrate that absence of KDM3A facilitates ciliogenesi ...[more]