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Interaction of iron oxide nanoparticles with human plasma

ABSTRACT: The Interaction of iron oxide nanoparticles with human plasma was studied.

INSTRUMENT(S): LTQ

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Robert Winkler

LAB HEAD: Dr. Robert Winkler

PROVIDER: PXD004441 | Pride | 2019-04-11

REPOSITORIES: Pride

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Plasma protein adsorption on Fe<sub>3</sub>O<sub>4</sub>-PEG nanoparticles activates the complement system and induces an inflammatory response.

Escamilla-Rivera V V Solorio-Rodríguez A A Uribe-Ramírez M M Lozano O O Lucas S S Chagolla-López A A Winkler R R De Vizcaya-Ruiz A A

International journal of nanomedicine 20190325

<h4>Background</h4>Understanding of iron oxide nanoparticles (IONP) interaction with the body milieu is crucial to guarantee their efficiency and biocompatibility in nanomedicine. Polymer coating to IONP, with polyethyleneglycol (PEG) and polyvinylpyrrolidone (PVP), is an accepted strategy to prevent toxicity and excessive protein binding.<h4>Aim</h4>The aim of this study was to investigate the feature of IONP adsorption of complement proteins, their activation and consequent inflammatory respon ...[more]

PMID: 30988608

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