Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
DISEASE(S): Acute Leukemia
SUBMITTER: Christoph Schaab
LAB HEAD: Christoph Schaab
PROVIDER: PXD004442 | Pride | 2017-05-02
REPOSITORIES: Pride
Roolf Catrin C Dybowski Nikolaj N Sekora Anett A Mueller Stefan S Knuebel Gudrun G Tebbe Andreas A Murua Escobar Hugo H Godl Klaus K Junghanss Christian C Schaab Christoph C
Molecular & cellular proteomics : MCP 20170427 7
Constitutively activating internal tandem duplication (ITD) alterations of the receptor tyrosine kinase FLT3 (Fms-like tyrosine kinase 3) are common in acute myeloid leukemia (AML) and classifies FLT3 as an attractive therapeutic target. So far, applications of FLT3 small molecule inhibitors have been investigated primarily in FLT3-ITD<sup>+</sup> patients. Only recently, a prolonged event-free survival has been observed in AML patients who were treated with the multikinase inhibitor sorafenib i ...[more]