Chemical translatome analysis in AML cells treated with different drug combinations
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ABSTRACT: Our prior research has shown that AML with FLT3-ITD is particularly susceptible to the combination of FLT3 inhibitors and protein synthesis inhibitors when compared to FLT3-WT. In this study, we employed a click chemistry-based approach to quantify the alterations in the translatome under FLT3 inhibition and protein synthesis inhibition in AML cells.
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Cell, Cell Suspension Culture
DISEASE(S): Acute Leukemia
SUBMITTER: Anskar Yu Hung Leung
LAB HEAD: Prof. Anskar Yu-hung Leung
PROVIDER: PXD047567 | Pride | 2024-03-26
REPOSITORIES: Pride
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