Dataset Information


Proteomics study of a human thyrotoxicosis mode

ABSTRACT: In this study we experimentally induced thyrotoxicosis in healthy volunteers to explore the effects of thyroxine excess on the plasma proteome. 16 healthy male subjects were sampled at baseline, 4 and 8 weeks under 250 µg/d thyroxine p.o., as well as 4 and 8 weeks after stopping the application.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo sapiens  

TISSUE(S): Blood Plasma

DISEASE(S): Not Available

SUBMITTER: Elke Hammer  

LAB HEAD: Uwe Völker

PROVIDER: PXD004815 | Pride | 2017-01-18


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Determinations of thyrotropin (TSH) and free thyroxine (FT4) represent the gold standard in evaluation of thyroid function. To screen for novel peripheral biomarkers of thyroid function and to characterize FT4-associated physiological signatures in human plasma we used an untargeted OMICS approach in a thyrotoxicosis model.A sample of 16 healthy young men were treated with levothyroxine for 8 weeks and plasma was sampled before the intake was started as well as at two points during treatment and  ...[more]

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