Proteomics

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Proteomics study of a human thyrotoxicosis mode


ABSTRACT: In this study we experimentally induced thyrotoxicosis in healthy volunteers to explore the effects of thyroxine excess on the plasma proteome. 16 healthy male subjects were sampled at baseline, 4 and 8 weeks under 250 µg/d thyroxine p.o., as well as 4 and 8 weeks after stopping the application.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo sapiens  

TISSUE(S): Blood Plasma

DISEASE(S): Not Available

SUBMITTER: Elke Hammer  

LAB HEAD: Uwe Völker

PROVIDER: PXD004815 | Pride | 2017-01-18

REPOSITORIES: pride

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Publications


Determinations of thyrotropin (TSH) and free thyroxine (FT4) represent the gold standard in evaluation of thyroid function. To screen for novel peripheral biomarkers of thyroid function and to characterize FT4-associated physiological signatures in human plasma we used an untargeted OMICS approach in a thyrotoxicosis model.A sample of 16 healthy young men were treated with levothyroxine for 8 weeks and plasma was sampled before the intake was started as well as at two points during treatment and  ...[more]

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